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Literature summary for 2.3.1.20 extracted from
- Diacylglycerol acyltransferase and monoacylglycerol acyltransferase from liver and intestine (1992), Methods Enzymol., 209, 98-104.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | intrinsic membrane protein | Rattus norvegicus | - |
- |
| microsome | active site on cytoplasmic surface | Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + 1,2-diacylglycerol | Rattus norvegicus | last reaction in triacylglycerol synthesis | CoA + triacylglycerol | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipocyte | isolated from parametrial adipose | Rattus norvegicus | - |
| intestinal mucosa | high activity | Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
| mammary gland | high activity | Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
specific activity in the nanomolar range in microsomal preparations, varies considerably between different tissues | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + 1,2-diacylglycerol | saturated fatty acyl-CoAs from C-8 to C-12 | Rattus norvegicus | CoA + triacylglycerol | - |
? | |
| acyl-CoA + 1,2-diacylglycerol | 2,3-diacylglycerol is acylated at 20% the rate of 1,2-isomer | Rattus norvegicus | CoA + triacylglycerol | - |
? | |
| acyl-CoA + 1,2-diacylglycerol | last reaction in triacylglycerol synthesis | Rattus norvegicus | CoA + triacylglycerol | - |
? | |
| palmitoyl-CoA + 1,2-diacylglycerol | - |
Rattus norvegicus | CoA + 1,2-diacyl-3-palmitoylglycerol | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| additional information | - |
assay at various temperatures from 24°C to 40°C | Rattus norvegicus |
| 25 | - |
assay at | Rattus norvegicus |
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Release 2023.1 (January 2023)
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