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Literature summary for 2.3.1.199 extracted from
- KCS1 encodes a fatty acid elongase 3-ketoacyl-CoA synthase affecting wax biosynthesis in Arabidopsis thaliana (1999), Plant J., 17, 119-130.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Arabidopsis thaliana | 16020 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 58300 | - |
x * 58300, calculated from amino acid sequence | Arabidopsis thaliana |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis thaliana | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cotyledon | - |
Arabidopsis thaliana | - |
| flower | - |
Arabidopsis thaliana | - |
| leaf | - |
Arabidopsis thaliana | - |
| root | - |
Arabidopsis thaliana | - |
| seed | - |
Arabidopsis thaliana | - |
| stem | - |
Arabidopsis thaliana | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| oleoyl-CoA + malonyl-CoA | in contrast to stearic acid-CoA, oleic acid-CoA serves as a less suitable substrate for elongation | Arabidopsis thaliana | ? | - |
? |  |
| stearoyl-CoA + malonyl-CoA | - |
Arabidopsis thaliana | CoA + 3-oxo-eicosanoyl-CoA + CO2 | major product | ? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 58300, calculated from amino acid sequence | Arabidopsis thaliana |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 3-ketoacyl-CoA synthase | - |
Arabidopsis thaliana |
| Fatty acid elongase | - |
Arabidopsis thaliana |
| Kcs1 | - |
Arabidopsis thaliana |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | complete loss of KCS1 expression results in decreases of up to 80% in the levels of C26 to C30 wax alcohols and aldehydes, while smaller effects are observed on the major wax components, i.e. the C29 alkanes and C29 ketones on leaves, stems and siliques. The loss of KCS1 expression does not result in complete loss of any individual wax component or significantly decrease the total wax load | Arabidopsis thaliana |
| physiological function | the enzyme plays a role in wax biosynthesis and is involved in both, the decarbonylation and acyl-reduction wax synthesis pathways | Arabidopsis thaliana |
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Release 2023.1 (January 2023)
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