Cloned (Comment) | Organism |
---|---|
gene abaI, DNA and amino acid sequence determination and analysis in the different clinical isolates | Acinetobacter sp. |
Protein Variants | Comment | Organism |
---|---|---|
additional information | inactivation of abaI gene in the chromosome of the Acinetobacter spp. S117 by insertion disruption, using the middle along with the flanking chromosomal DNA cloned into pUC18-based suicide delivery vector from Escherichia coli K12 carrying the pUC18-abaI::Tc plasmid, introduction of the plasmid by conjugation | Acinetobacter sp. |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine | Acinetobacter sp. | - |
an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone | - |
? | |
additional information | Acinetobacter sp. | five of the clinical isolates produce N-decanoyl homoserine lactone and two isolates produce acyl-homoserine lactone with a chain length equal to C12 | ? | - |
? | |
N-decanoyl -[acyl-carrier protein] + S-adenosyl-L-methionine | Acinetobacter sp. | - |
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-decanoyl -L-homoserine lactone | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Acinetobacter sp. | - |
clinical isolates, gene abaI | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine | - |
Acinetobacter sp. | an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone | - |
? | |
additional information | five of the clinical isolates produce N-decanoyl homoserine lactone and two isolates produce acyl-homoserine lactone with a chain length equal to C12 | Acinetobacter sp. | ? | - |
? | |
N-decanoyl -[acyl-carrier protein] + S-adenosyl-L-methionine | - |
Acinetobacter sp. | [acyl-carrier protein] + S-methyl-5'-thioadenosine + N-decanoyl -L-homoserine lactone | - |
? |
General Information | Comment | Organism |
---|---|---|
physiological function | abaI encodes an enzyme that is involved in production of N-acyl-homoserine lactones as quorum sensing signal molecules. The signal molecules aid in biofilm formation which in turn confer various properties of pathogenicity to the clinical isolates including drug resistance. Quorum sensing is a regulatory mechanism which enables bacteria to make collective decisions with respect to the expression of a specific set of genes. These includes genes involved in biofilm formation and virulence | Acinetobacter sp. |