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Literature summary for 2.3.1.180 extracted from

  • Du, Y.; Gisselberg, J.E.; Johnson, J.D.; Lee, P.J.; Prigge, S.T.; Bachmann, B.O.
    Lactococcus lactis fabH, encoding beta-ketoacyl-acyl carrier protein synthase, can be functionally replaced by the Plasmodium falciparum congener (2010), Appl. Environ. Microbiol., 76, 3959-3966.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.180

Cloned(Commentary)

Cloned (Comment) Organism
codon optimized gene expressed in Lactococcus lactis CL112 (fabH knockout strain) Plasmodium falciparum
expressed in Lactococcus lactis CL112 (fabH knockout strain) Lactococcus lactis

Inhibitors

Inhibitors Comment Organism Structure
cerulenin
-
 Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Lactococcus lactis Q9CHG0
-
-
Lactococcus lactis IL1403 Q9CHG0
-
-
Plasmodium falciparum O77078
-
-

Purification (Commentary)

Purification (Comment) Organism
truncated construct encoding residue 50 - 371 Plasmodium falciparum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + ACP acetyl-CoA:ACP transacylase activity Plasmodium falciparum acetyl-ACP + CoA
-
 ?
malonyl-ACP + acetyl-CoA
-
 Plasmodium falciparum CO2 + CoA + acetoacetyl-ACP
-
 ?
malonyl-ACP + acetyl-CoA
-
 Lactococcus lactis CO2 + CoA + acetoacetyl-ACP
-
 ?
malonyl-ACP + acetyl-CoA
-
 Lactococcus lactis IL1403 CO2 + CoA + acetoacetyl-ACP
-
 ?
malonyl-ACP + acyl-CoA
-
 Plasmodium falciparum CO2 + CoA + ?
-
 ?

Synonyms

Synonyms Comment Organism
beta-ketoacyl-acyl carrier protein synthase III
-
 Lactococcus lactis
beta-ketoacyl-acyl carrier protein synthase III also catalyzing acetyl-CoA:ACP transacylase reaction Plasmodium falciparum