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Literature summary for 2.3.1.180 extracted from

  • Revill, W.P.; Bibb, M.J.; Scheu, A.K.; Kieser, H.J.; Hopwood, D.A.
    beta-Ketoacyl acyl carrier protein synthase III (FabH) is essential for fatty acid biosynthesis in Streptomyces coelicolor A3(2) (2001), J. Bacteriol., 183, 3526-3530.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.180

Activating Compound

Activating Compound Comment Organism Structure
additional information the acpP gene product stimulates fatty acid biosynthesis in vitro Streptomyces coelicolor

Cloned(Commentary)

Cloned (Comment) Organism
gene fabH is transcribed in a gene cluster to produce a leaderless mRNA transcript, transcription analysis, genetic organization, overview Streptomyces coelicolor

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + malonyl-[acyl-carrier protein] Streptomyces coelicolor
-
 acetoacyl-[acyl-carrier protein] + CoA + CO2
-
 ?
acyl-CoA + malonyl-[acyl-carrier protein] Streptomyces coelicolor A3(2)
-
 acetoacyl-[acyl-carrier protein] + CoA + CO2
-
 ?
additional information Streptomyces coelicolor the enzyme is responsible for the initiation of fatty acid biosynthesis and for viability ?
-
 ?
additional information Streptomyces coelicolor A3(2) the enzyme is responsible for the initiation of fatty acid biosynthesis and for viability ?
-
 ?

Organism

Organism UniProt Comment Textmining
Streptomyces coelicolor P72392 gene fabH
-
Streptomyces coelicolor A3(2) P72392 gene fabH
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + malonyl-[acyl-carrier protein]
-
 Streptomyces coelicolor acetoacyl-[acyl-carrier protein] + CoA + CO2
-
 ?
acyl-CoA + malonyl-[acyl-carrier protein] the enzyme prefers long-chain fatty acids Streptomyces coelicolor acetoacyl-[acyl-carrier protein] + CoA + CO2
-
 ?
acyl-CoA + malonyl-[acyl-carrier protein]
-
 Streptomyces coelicolor A3(2) acetoacyl-[acyl-carrier protein] + CoA + CO2
-
 ?
acyl-CoA + malonyl-[acyl-carrier protein] the enzyme prefers long-chain fatty acids Streptomyces coelicolor A3(2) acetoacyl-[acyl-carrier protein] + CoA + CO2
-
 ?
additional information the enzyme is responsible for the initiation of fatty acid biosynthesis and for viability Streptomyces coelicolor ?
-
 ?
additional information the enzyme is responsible for the initiation of fatty acid biosynthesis and for viability Streptomyces coelicolor A3(2) ?
-
 ?

Synonyms

Synonyms Comment Organism
beta-ketoacyl acyl carrier protein synthase III
-
 Streptomyces coelicolor
FabH
-
 Streptomyces coelicolor