Crystallization (Comment) | Organism |
---|---|
purified recombinant enzyme in complex with lauroyl-CoA, X-ray diffraction structure determination and analysis at 1.85-2.3 A resolution, modeling | Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + malonyl-[acyl-carrier protein] | Mycobacterium tuberculosis | the enzyme initiates the fatty acid biosynthesis | acetoacetyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
acetyl-CoA + malonyl-[acyl-carrier protein] | Mycobacterium tuberculosis H37Rv | the enzyme initiates the fatty acid biosynthesis | acetoacetyl-[acyl-carrier protein] + CoA + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WNG3 | - |
- |
Mycobacterium tuberculosis H37Rv | P9WNG3 | - |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
acetyl-CoA + a malonyl-[acyl-carrier protein] = an acetoacetyl-[acyl-carrier protein] + CoA + CO2 | catalytic reaction mechanism for decarboxylation and condensation | Mycobacterium tuberculosis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + malonyl-[acyl-carrier protein] | - |
Mycobacterium tuberculosis | acetoacetyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
acetyl-CoA + malonyl-[acyl-carrier protein] | the enzyme initiates the fatty acid biosynthesis | Mycobacterium tuberculosis | acetoacetyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
acetyl-CoA + malonyl-[acyl-carrier protein] | - |
Mycobacterium tuberculosis H37Rv | acetoacetyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
acetyl-CoA + malonyl-[acyl-carrier protein] | the enzyme initiates the fatty acid biosynthesis | Mycobacterium tuberculosis H37Rv | acetoacetyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
lauroyl-CoA + malonyl-[acyl-carrier protein] | the primer substrate lauroyl-CoA is bound to subunit A, binding structure, lauroyl is bound in a channel | Mycobacterium tuberculosis | 3-oxo-myristoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
lauroyl-CoA + malonyl-[acyl-carrier protein] | the primer substrate lauroyl-CoA is bound to subunit A, binding structure, lauroyl is bound in a channel | Mycobacterium tuberculosis H37Rv | 3-oxo-myristoyl-[acyl-carrier protein] + CoA + CO2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | dimer packing analysis from crystal structure | Mycobacterium tuberculosis |
Synonyms | Comment | Organism |
---|---|---|
beta-ketoacyl-acyl carrier protein synthase III | - |
Mycobacterium tuberculosis |
FabH | - |
Mycobacterium tuberculosis |