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Literature summary for 2.3.1.176 extracted from

  • Liedhegner, E.S.; Vogt, C.D.; Sem, D.S.; Cunningham, C.W.; Hillard, C.J.
    Sterol carrier protein-2: binding protein for endocannabinoids (2014), Mol. Neurobiol., 50, 149-158.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.176

Application

Application Comment Organism
medicine SCP2 is a binding protein for endocannbinoids N-arachidonylethanolamine and 2-arachidonoylglycerol. N-arachidonylethanolamine and 2-arachidonoylglycerol associate with SCP2 at a putative cholesterol binding pocket with DeltaG values of ?3.6 and ?4.6 kcal per mol, respectively. SCP2-mediated transfer of cholesterol in vitro is inhibited by micromolar concentrations of N-arachidonylethanolamine, and heterologous expression of SCP2 in HEK-293 cells increases time-related accumulation of N-arachidonylethanolamine in a temperature-dependent fashion Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Homo sapiens
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HEK-293 cell
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 Homo sapiens
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General Information

General Information Comment Organism
physiological function SCP2 is a binding protein for endocannbinoids N-arachidonylethanolamine and 2-arachidonoylglycerol. N-arachidonylethanolamine and 2-arachidonoylglycerol associate with SCP2 at a putative cholesterol binding pocket with DeltaG values of -3.6 and -4.6 kcal per mol, respectively. SCP2-mediated transfer of cholesterol in vitro is inhibited by micromolar concentrations of N-arachidonylethanolamine, and heterologous expression of SCP2 in HEK-293 cells increases time-related accumulation of N-arachidonylethanolamine in a temperature-dependent fashion Homo sapiens