Literature summary for 2.3.1.17 extracted from

Huber, K.; Hofer, D.C.; Trefely, S.; Pelzmann, H.J.; Madreiter-Sokolowski, C.; Duta-Mare, M.; Schlager, S.; Trausinger, G.; Stryeck, S.; Graier, W.F.; Kolb, D.; Magnes, C.; Snyder, N.W.; Prokesch, A.; Kratky, D.; Madl, T.; Wellen, K.E.; Bogner-Strauss, J.G.
N-acetylaspartate pathway is nutrient responsive and coordinates lipid and energy metabolism in brown adipocytes (2019), Biochim. Biophys. Acta, 1866, 337-348 .

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q3UGX3	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brown adipose tissue	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
NAT8L	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	overexpression of Nat8L drains glucose-derived acetyl-CoA into the N-acetyl-L-aspartate pool at the expense of cellular lipids and certain amino acids. A combined activation of neutral and lysosomal (acid) lipolysis is responsible for the increased lipid degradation. Nat8l overexpression increases the number of autophagosomes and autolysosomes. Expression of Nat8l and aspartoacylase are nutritionally regulated and respond robustly to changes in glucose availability	Mus musculus

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Release 2023.1 (January 2023)