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Literature summary for 2.3.1.169 extracted from
- Function of the tunnel in acetylcoenzyme A synthase/carbon monoxide dehydrogenase (2006), J. Biol. Inorg. Chem., 11, 371-378.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| A219F | mutant designed to block the tunnel through which CO and CO2 migrate. Metal clusters are properly assembled but only slowly reducible by CO. Mutant shows impaired ability of CO to migrate through the tunnel to the C-cluster and reduced catalytic activity, no cooperative CO inhibition is observed | Moorella thermoacetica |
| A578C | mutant designed to block the tunnel through which CO and CO2 migrate. Metal clusters are properly assembled but only slowly reducible by CO. Mutant shows impaired ability of CO to migrate through the tunnel to the C-cluster and reduced catalytic activity, no cooperative CO inhibition is observed | Moorella thermoacetica |
| F70W | mutant designed to block the region that connects the tunnel at the betabeta interface with a water channel also located at the interface. Metal clusters are properly assembled but only slowly reducible by CO. Mutant shows impaired ability of CO to migrate through the tunnel to the C-cluster and reduced catalytic activity, no cooperative CO inhibition is observed | Moorella thermoacetica |
| L215F | mutant designed to block the tunnel through which CO and CO2 migrate. Metal clusters are properly assembled but only slowly reducible by CO. Mutant shows impaired ability of CO to migrate through the tunnel to the C-cluster and reduced catalytic activity, no cooperative CO inhibition is observed | Moorella thermoacetica |
| N101Q | mutant designed to block the region that connects the tunnel at the betabeta interface with a water channel also located at the interface. Metal clusters are properly assembled but only slowly reducible by CO. Mutant shows impaired ability of CO to migrate through the tunnel to the C-cluster and reduced catalytic activity, no cooperative CO inhibition is observed | Moorella thermoacetica |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Moorella thermoacetica | - |
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Release 2023.1 (January 2023)
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