Literature summary for 2.3.1.169 extracted from

Bramlett, M.R.; Stubna, A.; Tan, X.; Surovtsev, I.V.; Muenck, E.; Lindahl, P.A.
Moessbauer and EPR study of recombinant acetyl-CoA synthase from Moorella thermoacetica (2006), Biochemistry, 45, 8674-8685.

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Metals/Ions

Metals/Ions	Comment	Organism	Structure
Iron	Mössbauer and EPR study of enzyme alpha-subunit. About 70% contain [Fe4S4]1+ cubanes, and 30% contain [Fe4S4]2+ cubanes suggesting an extremely low [Fe4S4] 1+/2+ reduction potential	Moorella thermoacetica
Nickel	two electrons are required for reductive activation of enzyme, starting from the oxidized state containing Ni2+. A Ni0 state may form upon reductive activation and reform after each catalytic cycle	Moorella thermoacetica

Organism

Organism	UniProt	Comment	Textmining
Moorella thermoacetica	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
acetyl-CoA + a [Co(I) corrinoid Fe-S protein] = CO + CoA + a [methyl-Co(III) corrinoid Fe-S protein]	two electrons are required for reductive activation of enzyme, starting from the oxidized state containing Ni2+. A Ni0 state may form upon reductive activation and reform after each catalytic cycle	Moorella thermoacetica	a

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Release 2023.1 (January 2023)