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Literature summary for 2.3.1.169 extracted from

  • Svetlitchnyi, V.; Dobbek, H.; Meyer-Klaucke, W.; Meins, T.; Thiele, B.; Roemer, P.; Huber, R.; Meyer, O.
    A functional Ni-Ni-[4Fe-4S] cluster in the monomeric acetyl-CoA synthase from Carboxydothermus hydrogenoformans (2004), Proc. Natl. Acad. Sci. USA, 101, 446-451.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.169

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.28
-
 acetyl-CoA exchange activity: C14 from the carboxyl group of acetyl-CoA with C12 from CO Carboxydothermus hydrogenoformans

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Carboxydothermus hydrogenoformans 5737
-

Metals/Ions

Metals/Ions Comment Organism Structure
Cu the Ni in cluster A can be replaced by Cu yielding an inactive form of the acetyl-CoA synthase Carboxydothermus hydrogenoformans
Ni the functional cluster A of ACSCh contains a Ni-Ni-[4Fe-4S] site, in which the position proximal and distal to the cubane are occupied by Ni ions Carboxydothermus hydrogenoformans
Zn the Ni in cluster A can be replaced by Zn yielding an inactive form of the acetyl-CoA synthase Carboxydothermus hydrogenoformans

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
81700
-
 gel filtration Carboxydothermus hydrogenoformans
82900
-
 1 * 82900, the enzyme exists as a monomer as well as in a 1:1 molar complex with the 73300 Da CO dehydrogenase III, SDS-PAGE Carboxydothermus hydrogenoformans

Organism

Organism UniProt Comment Textmining
Carboxydothermus hydrogenoformans
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme catalyzes the exchange of 14C from the carboxyl group of acetyl-CoA with 12C from CO Carboxydothermus hydrogenoformans ?
-
 ?

Subunits

Subunits Comment Organism
monomer 1 * 82900, the enzyme exists as a monomer as well as in a 1:1 molar complex with the 73300 Da CO dehydrogenase III, SDS-PAGE Carboxydothermus hydrogenoformans

Synonyms

Synonyms Comment Organism
ACS/CODH
-
 Carboxydothermus hydrogenoformans

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
70
-
 exchange activity: C14 from the carboxyl group of acetyl-CoA with C12 from CO Carboxydothermus hydrogenoformans

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
 exchange activity: C14 from the carboxyl group of acetyl-CoA with C12 from CO Carboxydothermus hydrogenoformans