Application | Comment | Organism |
---|---|---|
synthesis | strategy to improve penicillin biosynthesis by Penicillium chrysogenum by reducing reactive and toxic metabolic byproducts, 2-oxoaldehydes. This is achieved by overexpressing the genes encoding glyoxalase I and II, which results in a 10% increase in penicillin titers relative to the control strain. The protein levels of isopenicillin N synthase and isopenicillin N acyltransferase are increased in the glyoxalase transformants, whereas their transcript levels remains unaltered | Penicillium chrysogenum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Penicillium chrysogenum | - |
- |
- |
Penicillium chrysogenum DS17690 | - |
- |
- |
Organism | Comment | Expression |
---|---|---|
Penicillium chrysogenum | in strains overexpressing the genes encoding glyoxalase I and II, the protein levels of isopenicillin N synthase and isopenicillin N acyltransferase are increased | up |