Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.164 extracted from

  • Scheckhuber, C.Q.; Veenhuis, M.; van der Klei, I.J.
    Improving penicillin biosynthesis in Penicillium chrysogenum by glyoxalase overproduction (2013), Metab. Eng., 18, 36-43.
    View publication on PubMed

Application

Application Comment Organism
synthesis strategy to improve penicillin biosynthesis by Penicillium chrysogenum by reducing reactive and toxic metabolic byproducts, 2-oxoaldehydes. This is achieved by overexpressing the genes encoding glyoxalase I and II, which results in a 10% increase in penicillin titers relative to the control strain. The protein levels of isopenicillin N synthase and isopenicillin N acyltransferase are increased in the glyoxalase transformants, whereas their transcript levels remains unaltered Penicillium chrysogenum

Organism

Organism UniProt Comment Textmining
Penicillium chrysogenum
-
-
-
Penicillium chrysogenum DS17690
-
-
-

Expression

Organism Comment Expression
Penicillium chrysogenum in strains overexpressing the genes encoding glyoxalase I and II, the protein levels of isopenicillin N synthase and isopenicillin N acyltransferase are increased up