Literature summary for 2.3.1.16 extracted from

Fidaleo, M.; Arnauld, S.; Clemencet, M.C.; Chevillard, G.; Royer, M.C.; De Bruycker, M.; Wanders, R.J.; Athias, A.; Gresti, J.; Clouet, P.; Degrace, P.; Kersten, S.; Espeel, M.; Latruffe, N.; Nicolas-Frances, V.; Mandard, S.
A role for the peroxisomal 3-ketoacyl-CoA thiolase B enzyme in the control of PPAR?-mediated upregulation of SREBP-2 target genes in the liver (2011), Biochimie, 93, 876-891.

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Synonyms

Synonyms	Comment	Organism
Thb	-	Mus musculus

General Information

General Information	Comment	Organism
physiological function	in mice deficient for isoform Thb, the degree of induction of peroxisomal beta-oxidation of palmitate mediated by Wy14,643, a synthetic compound activating nuclear hormone receptor PPARalpha, is significantly reduced in mice deficient for Thb, while mitochondrial beta-oxidation is unaltered. The thiolase step alone is responsible for the reduced peroxisomal beta-oxidation of fatty acids. Peroxisome proliferation in the liver after Wy-treatment is normal in Thb -/- mice	Mus musculus

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Release 2023.1 (January 2023)