Literature summary for 2.3.1.16 extracted from

Green, C.D.; Ozguden-Akkoc, C.G.; Wang, Y.; Jump, D.B.; Olson, L.K.
Role of fatty acid elongases in determination of de novo synthesized monounsaturated fatty acid species (2010), J. Lipid Res., 51, 1871-1877.

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Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
INS-1 cell	-	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
Elovl-5	-	Rattus norvegicus
Elovl-6	-	Rattus norvegicus

General Information

General Information	Comment	Organism
physiological function	Elovl-5 knockdown decreases elongation of 16:1,n-7. Elovl-5 over-expression increases synthesis of 18:1,n-7, however, this is dependent on stearoyl-CoA desaturase driven 16:1,n-7 availability	Rattus norvegicus
physiological function	knockdown of Elovl-6 decreases elongation of 16:0 and 16:1,n-7, resulting in accumulation of 16:1,n-7. Elovl-6 over-expression preferentially drives synthesis of 16:0 elongation products 18:0 and 18:1,n-9 but not 18:1,n-7	Rattus norvegicus

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Release 2023.1 (January 2023)