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Literature summary for 2.3.1.150 extracted from
- Closure of the oxide bridge in morphine biosynthesis (1994), Tetrahedron Lett., 35, 3897-3900.
No PubMed abstract available
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Acetyl-CoA + salutaridinol | Papaver sp. | the enzyme is involved in the biosynthetic pathway from L-Tyr to morphine | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Papaver sp. | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Papaver sp. |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cell suspension culture | - |
Papaver sp. | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + salutaridinol | - |
Papaver sp. | CoA + 7-O-acetylsalutaridinol | at higher pH values, the product 7-O-acetylsalutaridinol, spontaneously closes the 4-5 oxide bridge by allylic elimination to form the morphine precursor thebaine | ? | |
| Acetyl-CoA + salutaridinol | the enzyme is involved in the biosynthetic pathway from L-Tyr to morphine | Papaver sp. | ? | - |
? | |
| additional information | 7-epi-salutaridinol is inactive as substrate | Papaver sp. | ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 47 | - |
- |
Papaver sp. |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7 | 9 | - |
Papaver sp. |
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Release 2023.1 (January 2023)
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