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Literature summary for 2.3.1.15 extracted from

  • Wendel, A.A.; Cooper, D.E.; Ilkayeva, O.R.; Muoio, D.M.; Coleman, R.A.
    Glycerol-3-phosphate acyltransferase (GPAT)-1, but not GPAT4, incorporates newly synthesized fatty acids into triacylglycerol and diminishes fatty acid oxidation (2013), J. Biol. Chem., 288, 27299-27306.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + sn-glycerol 3-phosphate Mus musculus
-
CoA + 1-acyl-sn-glycerol 3-phosphate i.e. lysophosphatidic acid ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus Q61586
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
Mus musculus
-
hepatocyte primary hepatocyte Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + sn-glycerol 3-phosphate
-
Mus musculus CoA + 1-acyl-sn-glycerol 3-phosphate i.e. lysophosphatidic acid ?

Synonyms

Synonyms Comment Organism
glycerol-3-phosphate acyltransferase
-
Mus musculus
GPAT-1 isoform Mus musculus
GPAT-4 isoform Mus musculus
GPAT1
-
Mus musculus

General Information

General Information Comment Organism
malfunction in hepatocytes, the absence of isoform GPAT-1, but not GPAT-4, increases fatty acid oxidation and increases ketogenesis during fasting Mus musculus
metabolism isoform GPAT-1, but not GPAT-4, metabolizes fatty acid synthesized de novo from [14C]acetate and diverts fatty acids away from mitochondrial oxidation Mus musculus
physiological function isoform GPAT1-/- hepatocytes are not able to incorporate de novo synthesized fatty acid into triacylglycerol but oxidize twice as much exogenous fatty acid as controls. The hepatic content of long-chain acylcarnitine in fasted Gpat1-/- mice is 3-fold higher than in controls. When compared with control and isoform Gpat-/- mice, after the fasting-refeeding protocol, Gpat1-/- hepatic triacylglycerol is depleted, and long-chain acylcarnitine content is 3.5fold higher Mus musculus