Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Mus musculus | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + sn-glycerol 3-phosphate | Mus musculus | - |
CoA + 1-acyl-sn-glycerol 3-phosphate | i.e. lysophosphatidic acid | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Mus musculus | Q61586 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | - |
Mus musculus | - |
hepatocyte | primary hepatocyte | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + sn-glycerol 3-phosphate | - |
Mus musculus | CoA + 1-acyl-sn-glycerol 3-phosphate | i.e. lysophosphatidic acid | ? |
Synonyms | Comment | Organism |
---|---|---|
glycerol-3-phosphate acyltransferase | - |
Mus musculus |
GPAT-1 | isoform | Mus musculus |
GPAT-4 | isoform | Mus musculus |
GPAT1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | in hepatocytes, the absence of isoform GPAT-1, but not GPAT-4, increases fatty acid oxidation and increases ketogenesis during fasting | Mus musculus |
metabolism | isoform GPAT-1, but not GPAT-4, metabolizes fatty acid synthesized de novo from [14C]acetate and diverts fatty acids away from mitochondrial oxidation | Mus musculus |
physiological function | isoform GPAT1-/- hepatocytes are not able to incorporate de novo synthesized fatty acid into triacylglycerol but oxidize twice as much exogenous fatty acid as controls. The hepatic content of long-chain acylcarnitine in fasted Gpat1-/- mice is 3-fold higher than in controls. When compared with control and isoform Gpat-/- mice, after the fasting-refeeding protocol, Gpat1-/- hepatic triacylglycerol is depleted, and long-chain acylcarnitine content is 3.5fold higher | Mus musculus |