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Literature summary for 2.3.1.15 extracted from

  • Wydysh, E.A.; Medghalchi, S.M.; Vadlamudi, A.; Townsend, C.A.
    Design and synthesis of small molecule glycerol 3-phosphate acyltransferase inhibitors (2009), J. Med. Chem., 52, 3317-3327.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.15

Inhibitors

Inhibitors Comment Organism Structure
2-(2-phenylethylsulfonamido)benzoic acid
-
 Homo sapiens
2-(4-chlorophenylsulfonamido)benzoic acid
-
 Homo sapiens
2-(hexadecylsulfonamido)benzoic acid
-
 Homo sapiens
2-(methylsulfonamido)benzoic acid
-
 Homo sapiens
2-(nonylsulfonamido)benzoic acid
-
 Homo sapiens
2-(nonylsulfonamido)benzylphosphonic acid
-
 Homo sapiens
2-(octylsulfonamido)phenylphosphonic acid
-
 Homo sapiens
2-(pentylsulfonamido)benzylphosphonic acid
-
 Homo sapiens
2-(phenylmethylsulfonamido)benzoic acid
-
 Homo sapiens
2-(phenylsulfonamido)benzoic acid
-
 Homo sapiens
2-(tetradecylsulfonamido)benzoic acid
-
 Homo sapiens
3-(2-phenylethylsulfonamido)benzoic acid
-
 Homo sapiens
3-(4-chlorophenylsulfonamido)benzoic acid
-
 Homo sapiens
3-(nonylsulfonamido)benzoic acid
-
 Homo sapiens
3-(nonylsulfonamido)benzylphosphonic acid
-
 Homo sapiens
3-(nonylsulfonamidomethyl)benzoic acid
-
 Homo sapiens
3-(octylsulfonamido)phenylphosphonic acid
-
 Homo sapiens
3-(pentylsulfonamido)benzylphosphonic acid
-
 Homo sapiens
3-(pentylsulfonamidomethyl)benzoic acid
-
 Homo sapiens
3-(phenylmethylsulfonamido)benzoic acid
-
 Homo sapiens
3-(phenylsulfonamido)benzoic acid
-
 Homo sapiens
4-(2-phenylethylsulfonamido)benzoic acid
-
 Homo sapiens
4-(4-chlorophenylsulfonamido)benzoic acid
-
 Homo sapiens
4-(nonylsulfonamido)benzoic acid
-
 Homo sapiens
4-(nonylsulfonamido)benzylphosphonic acid
-
 Homo sapiens
4-(nonylsulfonamidomethyl)benzoic acid
-
 Homo sapiens
4-(octylsulfonamido)phenylphosphonic acid
-
 Homo sapiens
4-(pentylsulfonamido)benzylphosphonic acid
-
 Homo sapiens
4-(pentylsulfonamidomethyl)benzoic acid
-
 Homo sapiens
4-(phenylmethylsulfonamido)benzoic acid
-
 Homo sapiens
4-(phenylsulfonamido)benzoic acid
-
 Homo sapiens
5-chloro-2-(nonylsulfonamido)benzoic acid
-
 Homo sapiens
5-fluoro-2-(octylsulfonamido)benzoic acid
-
 Homo sapiens
5-hydroxy-2-(octylsulfonamido)benzoic acid
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glycerol 3-phosphate + palmitoyl-CoA
-
 Homo sapiens CoA + 1-palmitoyl-sn-glycerol 3-phosphate
-
 ?

Synonyms

Synonyms Comment Organism
glycerol-3-phosphate acyltransferase
-
 Homo sapiens
mtGPAT
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0174
-
-
 Homo sapiens 2-(tetradecylsulfonamido)benzoic acid
0.0183
-
-
 Homo sapiens 2-(hexadecylsulfonamido)benzoic acid
0.0247
-
 demonstrates the greatest inhibitory activity Homo sapiens 2-(nonylsulfonamido)benzoic acid
0.0318
-
-
 Homo sapiens 5-chloro-2-(nonylsulfonamido)benzoic acid
0.0628
-
-
 Homo sapiens 3-(nonylsulfonamido)benzylphosphonic acid
0.0665
-
-
 Homo sapiens 4-(nonylsulfonamidomethyl)benzoic acid
0.0724
-
-
 Homo sapiens 3-(octylsulfonamido)phenylphosphonic acid
0.0736
-
-
 Homo sapiens 2-(octylsulfonamido)phenylphosphonic acid
0.0739
-
-
 Homo sapiens 3-(nonylsulfonamido)benzoic acid
0.0757
-
-
 Homo sapiens 3-(4-chlorophenylsulfonamido)benzoic acid
0.0811
-
-
 Homo sapiens 2-(nonylsulfonamido)benzylphosphonic acid
0.0813
-
-
 Homo sapiens 4-(nonylsulfonamido)benzylphosphonic acid
0.0835
-
-
 Homo sapiens 3-(nonylsulfonamidomethyl)benzoic acid
0.0889
-
-
 Homo sapiens 4-(nonylsulfonamido)benzoic acid
0.089
-
-
 Homo sapiens 5-fluoro-2-(octylsulfonamido)benzoic acid
0.0953
-
-
 Homo sapiens 4-(octylsulfonamido)phenylphosphonic acid
0.107
-
-
 Homo sapiens 2-(4-chlorophenylsulfonamido)benzoic acid
0.108
-
-
 Homo sapiens 4-(4-chlorophenylsulfonamido)benzoic acid
0.116
-
-
 Homo sapiens 5-hydroxy-2-(octylsulfonamido)benzoic acid
0.129
-
-
 Homo sapiens 4-(nonylsulfonamidomethyl)benzoic acid
0.129
-
-
 Homo sapiens 2-(pentylsulfonamido)benzylphosphonic acid
0.132
-
-
 Homo sapiens 2-(methylsulfonamido)benzoic acid
0.138
-
-
 Homo sapiens 3-(phenylsulfonamido)benzoic acid
0.14
-
-
 Homo sapiens 2-(phenylmethylsulfonamido)benzoic acid
0.141
-
-
 Homo sapiens 3-(pentylsulfonamido)benzylphosphonic acid
0.146
-
-
 Homo sapiens 2-(phenylsulfonamido)benzoic acid
0.148
-
-
 Homo sapiens 4-(pentylsulfonamido)benzylphosphonic acid
0.151
-
-
 Homo sapiens 4-(phenylsulfonamido)benzoic acid
0.152
-
-
 Homo sapiens 2-(2-phenylethylsulfonamido)benzoic acid
0.164
-
-
 Homo sapiens 3-(2-phenylethylsulfonamido)benzoic acid
0.178
-
-
 Homo sapiens 3-(phenylmethylsulfonamido)benzoic acid
0.206
-
-
 Homo sapiens 4-(2-phenylethylsulfonamido)benzoic acid
0.217
-
-
 Homo sapiens 4-(pentylsulfonamidomethyl)benzoic acid
0.221
-
-
 Homo sapiens 4-(phenylmethylsulfonamido)benzoic acid
0.252
-
-
 Homo sapiens 4-(pentylsulfonamidomethyl)benzoic acid
0.31
-
-
 Homo sapiens 3-(pentylsulfonamidomethyl)benzoic acid