Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-(2-aminoethyl)benzene-sulfonyl fluoride | i.e. Pefabloc, complete inhibition of both enzyme activities at 0.05 mM | Homo sapiens | |
diisopropylfluorophosphate | complete inhibition of both enzyme activities at 20 mM | Homo sapiens | |
ether/ester-linked lysophospholipids | competitive | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
LDL particle | isolated from human plasma, different subfractions | Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | enzyme activities are decreased upon oxidation of LDL with Cu2+ | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme transfers short-chain fatty acids from platelet-activating factor PAF and its close ether- and ester-linked analogues to ether/ester-linked lysophospholipids, enzyme activity distribution within different LDL-subfactions, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Oxidation Stability | Organism |
---|---|
enzyme activities are decreased upon oxidation of LDL with Cu2+ | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | purified recombinant enzyme | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
activities of different LDL subfractions | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-acyl-sn-glycero-3-phosphocholine + 1-organyl-2-lyso-sn-glycero-3-phospholipid | 1-acyl-sn-glycero-3-phosphocholine is termed lyso-PC | Homo sapiens | 1-organyl-sn-glycero-3-phosphocholine + 1-acyl-2-lyso-sn-glycero-3-phospholipid | - |
? | |
1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-organyl-2-lyso-sn-glycero-3-phospholipid | 1-hexadecanoyl-sn-glycero-3-phosphocholine is termed C16:0 lyso-PC | Homo sapiens | 1-organyl-sn-glycero-3-phosphocholine + 1-O-hexadecanoyl-2-lyso-sn-glycero-3-phospholipid | - |
? | |
1-O-alkyl-sn-glycero-3-phosphocholine + 1-organyl-2-lyso-sn-glycero-3-phospholipid | 1-O-alkyl-sn-glycero-3-phosphocholine is termed lyso-PAF, artificial substrate | Homo sapiens | 1-organyl-sn-glycero-3-phosphocholine + 1-O-alkyl-2-lyso-sn-glycero-3-phospholipid | - |
? | |
1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + 1-organyl-2-lyso-sn-glycero-3-phospholipid | 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine is termed C16:0 lyso-PAF | Homo sapiens | 1-organyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-lyso-sn-glycero-3-phospholipid | - |
? | |
additional information | the enzyme transfers short-chain fatty acids from platelet-activating factor PAF and its close ether- and ester-linked analogues to ether/ester-linked lysophospholipids, enzyme activity distribution within different LDL-subfactions, overview | Homo sapiens | ? | - |
? | |
additional information | the enzyme also has a platelet-activating factor acetylhydrolase activity | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
platelet-activating factor transacetylase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
60 | - |
60 min, loss of 10% transacetylase activity, acetylhydrolase activity is completely stable | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |