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Literature summary for 2.3.1.149 extracted from

  • Tsoukatos, D.C.; Liapikos, T.A.; Tselepis, A.D.; Chapman, M.J.; Ninio, E.
    Platelet-activating factor acetylhydrolase and transacetylase activities in human plasma low-density lipoprotein (2001), Biochem. J., 357, 457-464.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
4-(2-aminoethyl)benzene-sulfonyl fluoride i.e. Pefabloc, complete inhibition of both enzyme activities at 0.05 mM Homo sapiens
diisopropylfluorophosphate complete inhibition of both enzyme activities at 20 mM Homo sapiens
ether/ester-linked lysophospholipids competitive Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
LDL particle isolated from human plasma, different subfractions Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Cu2+ enzyme activities are decreased upon oxidation of LDL with Cu2+ Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme transfers short-chain fatty acids from platelet-activating factor PAF and its close ether- and ester-linked analogues to ether/ester-linked lysophospholipids, enzyme activity distribution within different LDL-subfactions, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Oxidation Stability

Oxidation Stability Organism
enzyme activities are decreased upon oxidation of LDL with Cu2+ Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation purified recombinant enzyme Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
activities of different LDL subfractions Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-acyl-sn-glycero-3-phosphocholine + 1-organyl-2-lyso-sn-glycero-3-phospholipid 1-acyl-sn-glycero-3-phosphocholine is termed lyso-PC Homo sapiens 1-organyl-sn-glycero-3-phosphocholine + 1-acyl-2-lyso-sn-glycero-3-phospholipid
-
?
1-hexadecanoyl-sn-glycero-3-phosphocholine + 1-organyl-2-lyso-sn-glycero-3-phospholipid 1-hexadecanoyl-sn-glycero-3-phosphocholine is termed C16:0 lyso-PC Homo sapiens 1-organyl-sn-glycero-3-phosphocholine + 1-O-hexadecanoyl-2-lyso-sn-glycero-3-phospholipid
-
?
1-O-alkyl-sn-glycero-3-phosphocholine + 1-organyl-2-lyso-sn-glycero-3-phospholipid 1-O-alkyl-sn-glycero-3-phosphocholine is termed lyso-PAF, artificial substrate Homo sapiens 1-organyl-sn-glycero-3-phosphocholine + 1-O-alkyl-2-lyso-sn-glycero-3-phospholipid
-
?
1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + 1-organyl-2-lyso-sn-glycero-3-phospholipid 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine is termed C16:0 lyso-PAF Homo sapiens 1-organyl-sn-glycero-3-phosphocholine + 1-O-hexadecyl-2-lyso-sn-glycero-3-phospholipid
-
?
additional information the enzyme transfers short-chain fatty acids from platelet-activating factor PAF and its close ether- and ester-linked analogues to ether/ester-linked lysophospholipids, enzyme activity distribution within different LDL-subfactions, overview Homo sapiens ?
-
?
additional information the enzyme also has a platelet-activating factor acetylhydrolase activity Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
platelet-activating factor transacetylase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
60
-
60 min, loss of 10% transacetylase activity, acetylhydrolase activity is completely stable Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens