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Literature summary for 2.3.1.149 extracted from
- A novel CoA-independent transacetylase produces the ethanolamine plasmalogen and acetyl analogs of platelet-activating factor (PAF) with PAF as the actetate donor in HL-60 cells (1992), J. Biol. Chem., 267, 19992-20001.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Mepacrine | - |
Homo sapiens |  |
| p-bromophenacyl bromide | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.012 | - |
Hexadecyl-acetyl-sn-glycero-3-phosphocholine | - |
Homo sapiens | |
| 0.1064 | - |
alk-1-enyllyso-sn-glycero-phosphoethanolamine | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | the enzyme may participate in the biosynthesis of ethanolamine plasmalogen and acyl analogs of platelet-activating factor, in vivo, finetuning of platelet-activating factor biological responses and cross-talk between de novo and remodeling pathways of platelet biosynthesis | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HL-60 cell | - |
Homo sapiens | - |
| pulmonary artery endothelial cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine + acyllyso-sn-glycero-3-phosphate | - |
Homo sapiens | ? | - |
? | |
| 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine + acyllyso-sn-glycero-3-phosphoinositol | - |
Homo sapiens | ? | - |
? | |
| 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine + acyllyso-sn-glycero-3-phosphoserine | - |
Homo sapiens | ? | - |
? | |
| 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine + alkyllyso-sn-glycero-3-phosphate | - |
Homo sapiens | ? | - |
? | |
| 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine + cis-9-octadecen-1-ol | - |
Homo sapiens | ? | - |
? | |
| 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine + lysoplasmalogen | 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine is platelet-activating factor | Homo sapiens | 1-Alk-1-enyl-2-acetyl-sn-glycero-3-phosphoethanolamine + ? | - |
? | |
| 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine + radyllyso-sn-glycero-3-phosphocholine | - |
Homo sapiens | ? | - |
? | |
| 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine + radyllyso-sn-glycero-3-phosphoethanolamine | - |
Homo sapiens | ? | - |
? | |
| Hexadecyl-acetyl-sn-glycero-3-phosphocholine + alk-1-enyllyso-sn-glycero-phosphoethanolamine | - |
Homo sapiens | ? | - |
? | |
| additional information | the enzyme may participate in the biosynthesis of ethanolamine plasmalogen and acyl analogs of platelet-activating factor, in vivo, finetuning of platelet-activating factor biological responses and cross-talk between de novo and remodeling pathways of platelet biosynthesis | Homo sapiens | ? | - |
? | |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 15 | 24 | active between 15°C and 24°C | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
- |
Homo sapiens |
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