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Literature summary for 2.3.1.148 extracted from
- The role of transacylases in the metabolism of arachidonate and platelet activating factor (1992), Prog. Lipid Res., 31, 65-86.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | strong | Rattus norvegicus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0015 | - |
1-hexadecyl-2-lyso-glycerophosphocholine | - |
Oryctolagus cuniculus | |
| 0.0038 | - |
1-acyl-2-lyso-glycerophosphocholine | - |
Oryctolagus cuniculus | |
| 0.017 | - |
1-palmitoyl-2-lyso-glycerophosphocholine | - |
Rattus norvegicus | |
| 0.076 | - |
lyso-phosphatidylserine | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
| microsome | - |
Oryctolagus cuniculus | - |
- |
| microsome | - |
Canis lupus familiaris | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Canis lupus familiaris | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| alveolar macrophage | - |
Oryctolagus cuniculus | - |
| heart | - |
Canis lupus familiaris | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Oryctolagus cuniculus | - |
| lung | - |
Rattus norvegicus | - |
| lymphocyte | - |
Mus musculus | - |
| macrophage | - |
Mus musculus | - |
| platelet | - |
Homo sapiens | - |
| platelet | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-Acyl-2-arachidonoyl-glycerophosphocholine + lyso-phosphatidylethanolamine | transfer of arachidonate occurs through a bidirectional movement | Mus musculus | 1-Acyl-2-lyso-glycerophosphocholine + arachidonoylphosphatidylethanolamine | - |
? | |
| 1-acyl-2-arachidonoyl-sn-glycero-3-phosphoinositol + lyso-phosphatidylcholine | - |
Mus musculus | 1-acyl-2-lyso-sn-glycero-3-phosphoinositol + ? | - |
? | |
| 1-Acyl-2-arachidonoyl-sn-glycero-3-phosphophoinositol + lyso-phosphatidylethanolamine | unidirectional transfer process of arachidonate | Mus musculus | 1-Acyl-2-lyso-sn-glycero-3-phosphoinositol + arachidonoylphosphatidylethanolamine | - |
? | |
| 1-acyl-2-lyso-glycerophosphocholine + arachidonoylphosphatidylethanolamine | - |
Oryctolagus cuniculus | 1-acyl-2-arachidonoyl-glycerophosphocholine + lyso-phosphatidylethanolamine | - |
r | |
| 1-Hexadecyl-2-lyso-glycerophosphocholine + phospholipid | - |
Oryctolagus cuniculus | ? | - |
? | |
| 1-palmitoyl-2-lyso-glycerophosphocholine + arachidonoylphosphatidylethanolamine | - |
Rattus norvegicus | 1-palmitoyl-2-arachidonoyl-glycerophosphocholine + lyso-phosphatidylethanolamine | - |
r | |
| lyso-Pasmenylethanolamine + phospholipid | - |
Homo sapiens | ? | - |
? | |
| lyso-Phosphatidylethanolamine + phospholipid | - |
Homo sapiens | Phosphatidylethanolamine + lyso-phospholipid | - |
? | |
| lyso-Phosphatidylinositol + phospholipid | - |
Homo sapiens | Phosphatidylinositol + lyso-phospholipid | - |
? | |
| lyso-Phosphatidylserine + phospholipid | - |
Homo sapiens | Phosphatidylserine + lyso-phospholipid | - |
? | |
| additional information | arachidonate and linoleate at the sn-2 position of phosphatidylcholine can be transferred to lyso-phosphatidylethanolamine. The transfer of 16:0, 18:0, and 18:1 acyl moieties at the sn-2-position of phosphatidylcholine is negligible | Rattus norvegicus | ? | - |
? | |
| additional information | more efficient transfer of arachidonate from phosphatidylcholine to the ethanolamine-containing phospholipids than from phosphatidylinositol | Homo sapiens | ? | - |
? | |
| Phosphatidylcholine + lyso-phosphatidylethanolamine | - |
Mus musculus | lyso-Phosphatidylcholine + phosphatidylethanolamine | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 4.5 | - |
bimodal pH-optimum, at pH 4.5 and at pH 7.5. The activity is 4-5times higher at pH 4.5 than at pH 7.5 | Canis lupus familiaris |
| 7.5 | - |
- |
Rattus norvegicus |
| 7.5 | - |
bimodal pH-optimum, at pH 7.5 and at pH 4.5 | Canis lupus familiaris |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| CoA | - |
Canis lupus familiaris | |
| CoA | required | Mus musculus | |
| CoA | required | Homo sapiens | |
| CoA | required | Rattus norvegicus | |
| CoA | required | Oryctolagus cuniculus | |
| CoA | Km: 0.0015 mM, lung enzyme, with lyso-phosphatidylethanolamine as substrate | Rattus norvegicus | |
| CoA | Km: 0.014 mM, liver enzyme, with 2-lyso-sn-phosphatidylinositol as substrate | Rattus norvegicus | |
| CoA | Km: 0.0014 mM | Homo sapiens | |
| CoA | Km: 0.0014 mM | Oryctolagus cuniculus | |
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