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Literature summary for 2.3.1.137 extracted from

  • Le Borgne, F.; Ben Mohamed, A.; Logerot, M.; Garnier, E.; Demarquoy, J.
    Changes in carnitine octanoyltransferase activity induce alteration in fatty acid metabolism (2011), Biochem. Biophys. Res. Commun., 409, 699-704.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expression in HepG2 cell Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
peroxisome
-
 Homo sapiens 5777
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UKG9
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-
Hep-G2 cell
-
 Homo sapiens
-
NB-69 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
CrOT
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function overexpression and knock-down of the enzyme gene in a model of hepatic cells. Increase in enzymic activity induces a decrease in medium chain fatty acid and very long chaichain fatty acid levels in the cell. These changes are accompanied by an increase in the level of mRNA encoding enzymes of the peroxisomal beta oxidation, while there is no change in mitochondrial function. A decrease in carnitine ocatanoyltransferase activity has the opposite effect. Results suggest that carnitine ocatanoyltransferase activity, by controlling the peroxisomal amount of medium chain acyls, may control the peroxisomal oxidative pathway Homo sapiens