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Literature summary for 2.3.1.137 extracted from
- Molecular cloning and expression of human carnitine octanoyltransferase: Evidence for its role in the peroxisomal beta-oxidation of branched-chain fatty acids (1999), Biochem. Biophys. Res. Commun., 263, 213-218.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| cDNA PCR amplified, cloned in yeast expression vector pEL26 and expressed in Saccharomyces cerevisiae | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| peroxisome | - |
Bos taurus | 5777 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 66000 | - |
recombinant enzyme, expressed in Saccharomyces cerevisiae | Homo sapiens |
| 70000 | - |
calculated from cDNA sequence | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + L-carnitine | Bos taurus | - |
acyl-L-carnitine + CoA | - |
r |  |
| acyl-CoA + L-carnitine | Homo sapiens | - |
acyl-L-carnitine + CoA | - |
r | |
| acyl-CoA + L-carnitine | Rattus norvegicus | - |
acyl-L-carnitine + CoA | - |
r | |
| L-carnitine + octanoyl-CoA | Bos taurus | - |
octanoyl-L-carnitine + CoA | - |
r | |
| octanoyl-L-carnitine + CoA | Bos taurus | - |
L-carnitine + octanoyl-CoA | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Bos taurus | O19094 | SwissProt accession number U65745 | - |
| Homo sapiens | Q9UKG9 | GenBank accession number AF168793 | - |
| no activity in Saccharomyces cerevisiae | - |
- |
- |
| Rattus norvegicus | P11466 | SwissProt accession number U26033 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fibroblast | skin fibroblast | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4,8-dimethylnonanoyl-CoA + L-carnitine | - |
Homo sapiens | 4,8-dimethylnonanoyl-L-carnitine + CoA | - |
r | |
| 4,8-dimethylnonanoyl-L-carnitine + CoA | - |
Homo sapiens | 4,8-dimethylnonanoyl-CoA + L-carnitine | - |
r | |
| acyl-CoA + L-carnitine | - |
Bos taurus | acyl-L-carnitine + CoA | - |
r | |
| acyl-CoA + L-carnitine | - |
Homo sapiens | acyl-L-carnitine + CoA | - |
r | |
| acyl-CoA + L-carnitine | - |
Rattus norvegicus | acyl-L-carnitine + CoA | - |
r | |
| decanoyl-CoA + L-carnitine | - |
Homo sapiens | L-decanoyl-L-carnitine + CoA | - |
r | |
| dodecanoyl-CoA + L-carnitine | - |
Bos taurus | L-dodecanoyl-L-carnitine + CoA | - |
r | |
| dodecanoyl-L-carnitine + CoA | - |
Bos taurus | dodecanoyl-CoA + L-carnitine | - |
r | |
| heptanoyl-CoA + L-carnitine | - |
Homo sapiens | L-heptanoyl-L-carnitine + CoA | - |
r | |
| hexadecanoyl-L-carnitine + CoA | - |
Bos taurus | hexadecanoyl-CoA + L-carnitine | - |
r | |
| hexanoyl-CoA + L-carnitine | - |
Bos taurus | CoA + L-hexanoylcarnitine | - |
r | |
| L-carnitine + octanoyl-CoA | - |
Bos taurus | octanoyl-L-carnitine + CoA | - |
r | |
| L-hexanoylcarnitine + CoA | - |
Bos taurus | hexanoyl-CoA + L-carnitine | - |
r | |
| additional information | 2,6-dimethyl-heptanoyl-CoA is not a substrate | Homo sapiens | ? | - |
? | |
| octanoyl-L-carnitine + CoA | - |
Bos taurus | L-carnitine + octanoyl-CoA | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | - |
Bos taurus |
| monomer | 1 * 66000, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| COT | - |
Bos taurus |
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Release 2023.1 (January 2023)
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