BRENDA - Enzyme Database show
show all sequences of 2.3.1.137

Involvement of carnitine acyltransferases in peroxisomal fatty acid metabolism by the yeast Pichia guilliermondii

Pagot, Y.; Belin, J.M.; Appl. Environ. Microbiol. 62, 3864-3867 (1996)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
2-bromodecanoic acid
-
Meyerozyma guilliermondii
2-bromooctanoic acid
-
Meyerozyma guilliermondii
2-bromopalmitic acid
potent inhibitor
Meyerozyma guilliermondii
chlorpromazine
-
Meyerozyma guilliermondii
tetradecylglycidic acid
-
Meyerozyma guilliermondii
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Meyerozyma guilliermondii
5829
-
cytosol
-
Rattus norvegicus
5829
-
peroxisome
-
Meyerozyma guilliermondii
5777
-
peroxisome
-
Rattus norvegicus
5777
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
acyl-CoA + L-carnitine
Rattus norvegicus
-
acyl-L-carnitine + CoA
-
-
r
acyl-CoA + L-carnitine
Meyerozyma guilliermondii
metabolic pathway of peroxisomal beta-oxidation in yeasts
acyl-L-carnitine + CoA
-
-
r
acyl-L-carnitine + CoA
Rattus norvegicus
-
acyl-CoA + L-carnitine
-
-
r
acyl-L-carnitine + CoA
Meyerozyma guilliermondii
-
acyl-CoA + L-carnitine
-
-
r
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Meyerozyma guilliermondii
-
yeast
-
Rattus norvegicus
-
rat
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
hepatocyte
-
Rattus norvegicus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acyl-CoA + L-carnitine
-
486301
Rattus norvegicus
acyl-L-carnitine + CoA
-
-
-
r
acyl-CoA + L-carnitine
-
486301
Meyerozyma guilliermondii
acyl-L-carnitine + CoA
-
-
-
r
acyl-CoA + L-carnitine
metabolic pathway of peroxisomal beta-oxidation in yeasts
486301
Meyerozyma guilliermondii
acyl-L-carnitine + CoA
-
-
-
r
acyl-L-carnitine + CoA
-
486301
Rattus norvegicus
acyl-CoA + L-carnitine
-
-
-
r
acyl-L-carnitine + CoA
-
486301
Meyerozyma guilliermondii
acyl-CoA + L-carnitine
-
-
-
r
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
2-bromodecanoic acid
-
Meyerozyma guilliermondii
2-bromooctanoic acid
-
Meyerozyma guilliermondii
2-bromopalmitic acid
potent inhibitor
Meyerozyma guilliermondii
chlorpromazine
-
Meyerozyma guilliermondii
tetradecylglycidic acid
-
Meyerozyma guilliermondii
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Meyerozyma guilliermondii
5829
-
cytosol
-
Rattus norvegicus
5829
-
peroxisome
-
Meyerozyma guilliermondii
5777
-
peroxisome
-
Rattus norvegicus
5777
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
acyl-CoA + L-carnitine
Rattus norvegicus
-
acyl-L-carnitine + CoA
-
-
r
acyl-CoA + L-carnitine
Meyerozyma guilliermondii
metabolic pathway of peroxisomal beta-oxidation in yeasts
acyl-L-carnitine + CoA
-
-
r
acyl-L-carnitine + CoA
Rattus norvegicus
-
acyl-CoA + L-carnitine
-
-
r
acyl-L-carnitine + CoA
Meyerozyma guilliermondii
-
acyl-CoA + L-carnitine
-
-
r
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
hepatocyte
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acyl-CoA + L-carnitine
-
486301
Rattus norvegicus
acyl-L-carnitine + CoA
-
-
-
r
acyl-CoA + L-carnitine
-
486301
Meyerozyma guilliermondii
acyl-L-carnitine + CoA
-
-
-
r
acyl-CoA + L-carnitine
metabolic pathway of peroxisomal beta-oxidation in yeasts
486301
Meyerozyma guilliermondii
acyl-L-carnitine + CoA
-
-
-
r
acyl-L-carnitine + CoA
-
486301
Rattus norvegicus
acyl-CoA + L-carnitine
-
-
-
r
acyl-L-carnitine + CoA
-
486301
Meyerozyma guilliermondii
acyl-CoA + L-carnitine
-
-
-
r
Other publictions for EC 2.3.1.137
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
718746
Le Borgne
Changes in carnitine octanoylt ...
Homo sapiens
Biochem. Biophys. Res. Commun.
409
699-704
2011
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1
1
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686028
Westin
Short- and medium-chain carnit ...
Mus musculus 129/Sv, Mus musculus
Cell. Mol. Life Sci.
65
982-990
2008
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659511
Jogl
Crystal structure of mouse car ...
Mus musculus
J. Biol. Chem.
280
738-744
2005
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1
4
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675265
Gloerich
A phytol-enriched diet induces ...
Mus musculus
J. Lipid Res.
46
716-726
2005
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657546
Jogl
Structure and function of carn ...
Bos taurus
Ann. N. Y. Acad. Sci.
1033
17-29
2004
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3
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2
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2
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659372
Cordente
Redesign of carnitine acetyltr ...
Rattus norvegicus
J. Biol. Chem.
279
33899-33908
2004
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1
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2
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2
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1
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3
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1
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9
2
1
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1
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1
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2
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2
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1
1
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1
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9
2
1
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1
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659306
Morillas
Identification of conserved am ...
Rattus norvegicus
J. Biol. Chem.
278
9058-9063
2003
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1
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1
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486310
Morillas
Structural model of a malonyl- ...
Rattus norvegicus
J. Biol. Chem.
277
11473-11480
2002
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4
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1
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4
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1
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1
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486308
Hegardt
Post-transcriptional regulatio ...
Rattus norvegicus
Biochem. Soc. Trans.
29
316-320
2001
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1
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2
3
1
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3
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1
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1
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3
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486309
Morillas
Structural model of the cataly ...
Rattus norvegicus
J. Biol. Chem.
276
45001-45008
2001
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1
5
2
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1
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2
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2
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2
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2
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486307
Morillas
-
Inhibition by etomoxir of rat ...
Bos taurus, no activity in Saccharomyces cerevisiae, Rattus norvegicus
Biochem. J.
351
495-502
2000
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7
1
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486304
Caudevilla
Processing of carnitine octano ...
Bos taurus, Homo sapiens, Rattus norvegicus
Adv. Exp. Med. Biol.
466
95-102
1999
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7
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486305
Ferdinandusse
Molecular cloning and expressi ...
Bos taurus, Homo sapiens, no activity in Saccharomyces cerevisiae, Rattus norvegicus
Biochem. Biophys. Res. Commun.
263
213-218
1999
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1
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2
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2
6
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7
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1
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16
2
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1
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6
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1
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16
2
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486306
Ramsay
Selective modulation of carnit ...
Bos taurus
Adv. Exp. Med. Biol.
466
103-109
1999
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2
7
2
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1
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4
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2
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4
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486302
Cronin
The conserved serine-threonine ...
Bos taurus
Biochem. Biophys. Res. Commun.
238
784-789
1997
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1
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13
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486303
Cronin
cDNA cloning, recombinant expr ...
Bos taurus
Eur. J. Biochem.
247
1029-1037
1997
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1
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1
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1
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1
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486301
Pagot
Involvement of carnitine acylt ...
Meyerozyma guilliermondii, Rattus norvegicus
Appl. Environ. Microbiol.
62
3864-3867
1996
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5
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2
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5
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5
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4
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1
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5
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486300
Chung
Properties of the medium chain ...
Rattus norvegicus
J. Biol. Chem.
268
4519-4524
1993
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4
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4
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2
2
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3
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1
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3
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11
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4
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4
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2
2
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1
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3
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11
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486299
Nic A'Bhaird
Malonyl-CoA inhibition of pero ...
Rattus norvegicus
Biochem. J.
286
637-640
1992
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7
2
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2
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486298
Lilly
The medium-chain carnitine acy ...
Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Arch. Biochem. Biophys.
280
167-174
1990
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1
3
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7
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8
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165
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1
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4
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1
14
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1
14
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486297
Healy
Enzymes of carnitine acylation ...
Bos taurus, Mus musculus, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Biochem. J.
249
231-237
1988
-
-
-
-
-
-
1
-
6
-
1
10
-
166
-
-
1
-
-
3
-
-
22
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
6
-
1
10
-
-
-
1
-
3
-
-
22
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486296
Bird
Carnitine acyltransferase acti ...
Mus musculus, Rattus norvegicus, Rattus norvegicus Wistar
Biochem. J.
226
323-330
1985
-
-
-
-
-
-
1
-
3
-
-
12
-
168
-
-
-
-
-
3
-
-
12
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
3
-
-
12
-
-
-
-
-
3
-
-
12
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486295
Farrell
Properties of purified carniti ...
Bos taurus, Canis lupus familiaris, Mus musculus, Rattus norvegicus
J. Biol. Chem.
259
13089-13095
1984
1
-
-
-
-
-
4
4
9
-
3
17
-
6
-
-
2
-
-
6
-
-
26
-
-
-
-
-
1
1
-
-
1
-
-
1
-
-
-
-
-
-
-
4
1
4
9
-
3
17
-
-
-
2
-
6
-
-
26
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
486294
Farrell
Carnitine octanoyltransferase ...
Bos taurus, Mus musculus, Rattus norvegicus
Arch. Biochem. Biophys.
222
123-132
1983
-
-
-
-
-
-
-
7
10
-
1
9
-
6
-
-
2
-
-
6
1
4
20
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
7
10
-
1
9
-
-
-
2
-
6
1
4
20
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
486293
Saggerson
Malonyl CoA inhibition of carn ...
Rattus norvegicus
FEBS Lett.
137
124-128
1982
-
-
-
-
-
-
1
-
1
-
-
3
-
1
-
-
-
-
-
2
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
3
-
-
-
-
-
2
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486292
Markwell
-
Comparison of the carnitine ac ...
Columba sp., Rattus norvegicus, Sus scrofa
Arch. Biochem. Biophys.
176
479-488
1976
-
-
-
-
-
1
-
-
3
-
1
5
-
3
-
-
1
-
-
4
-
-
30
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
3
-
1
5
-
-
-
1
-
4
-
-
30
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
486291
Solberg
Acyl group specificity of mito ...
Bos taurus, Mus musculus, Mus musculus NMRI/Bom, Rattus norvegicus, Rattus norvegicus Wistar/Moell
Biochim. Biophys. Acta
360
101-112
1974
-
-
-
-
-
-
9
-
3
-
-
11
-
5
-
-
-
-
-
3
-
-
41
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
9
-
-
3
-
-
11
-
-
-
-
-
3
-
-
41
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486290
Solberg
Different carnitine acyltransf ...
Bos taurus, Canis lupus familiaris, Columba sp., Homo sapiens, Mus musculus, Oryctolagus cuniculus, Platyrrhini, Rattus norvegicus, Sus scrofa
Biochim. Biophys. Acta
280
422-433
1972
-
-
-
-
-
-
-
1
4
-
-
17
-
9
-
-
1
-
-
10
-
1
47
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
4
-
-
17
-
-
-
1
-
10
-
1
47
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-