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Literature summary for 2.3.1.137 extracted from
- Properties of the medium chain/long chain carnitine acyltransferase purified from rat liver microsomes (1993), J. Biol. Chem., 268, 4519-4524.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Aminocarnitine | - |
Rattus norvegicus |  |
| D-carnitine | - |
Rattus norvegicus | |
| etomoxiryl-CoA | - |
Rattus norvegicus | |
| malonyl-CoA | microsomal COT, no inhibition of the mitochondrial enzyme | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
| microsome | - |
Rattus norvegicus | - |
- |
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
| peroxisome | - |
Rattus norvegicus | 5777 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 50000 | 55000 | SDS-PAGE | Rattus norvegicus |
| 53000 | - |
Western blot, polyclonal antibody reaction | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + L-carnitine | Rattus norvegicus | - |
acyl-L-carnitine + CoA | - |
r | |
| acyl-L-carnitine + CoA | Rattus norvegicus | - |
acyl-CoA + L-carnitine | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
rat | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-methylglutaryl-CoA + L-carnitine | little capacity to use this substrate | Rattus norvegicus | 3-methylglutaryl-L-carnitine + CoA | - |
r | |
| 3-methylglutaryl-L-carnitine + CoA | - |
Rattus norvegicus | 3-methylglutaryl-CoA + L-carnitine | - |
r | |
| acyl-CoA + L-carnitine | - |
Rattus norvegicus | acyl-L-carnitine + CoA | - |
r | |
| acyl-L-carnitine + CoA | - |
Rattus norvegicus | acyl-CoA + L-carnitine | - |
r | |
| beta-hydroxy-beta-methylglutaryl-L-carnitine + CoA | - |
Rattus norvegicus | beta-hydroxy-beta-methylglutaryl-CoA + L-carnitine | - |
r | |
| decanoyl-CoA + L-carnitine | - |
Rattus norvegicus | L-decanoyl-L-carnitine + CoA | - |
r | |
| decanoyl-L-carnitine + CoA | - |
Rattus norvegicus | decanoyl-CoA + L-carnitine | - |
r | |
| pivaloyl-CoA + L-carnitine | little capacity to use this substrate | Rattus norvegicus | L-pivaloyl-L-carnitine + CoA | - |
r | |
| pivaloyl-L-carnitine + CoA | - |
Rattus norvegicus | pivaloyl-CoA + L-carnitine | - |
r | |
| valproyl-CoA + L-carnitine | little capacity to use this substrate | Rattus norvegicus | L-valproyl-L-carnitine + CoA | - |
r | |
| valproyl-L-carnitine + CoA | - |
Rattus norvegicus | valproyl-CoA + L-carnitine | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| COT | - |
Rattus norvegicus |
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