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Literature summary for 2.3.1.135 extracted from
- Vitamin A metabolism in benign and malignant melanocytic skin cells: importance of lecithin/retinol acyltransferase and RPE65 (2012), J. Cell. Physiol., 227, 718-728.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| LRAT, quantitative real-time RT-PCR expression analysis in melanoma cell lines | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | siRNA knockdown of LRAT and RPE65 expression | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphatidylcholine + retinol-[cellular-retinol-binding-protein] | Homo sapiens | - |
2-acylglycerophosphocholine + retinyl-ester-[cellular-retinol-binding-protein] | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HaCaT cell | - |
Homo sapiens | - |
| keratinocyte | - |
Homo sapiens | - |
| Ma-Mel-04 cell | - |
Homo sapiens | - |
| Ma-Mel-11 cell | - |
Homo sapiens | - |
| Ma-Mel-12 cell | - |
Homo sapiens | - |
| melanocyte | epidermal | Homo sapiens | - |
| melanoma cell | diverse cell lines | Homo sapiens | - |
| MeWo cell | - |
Homo sapiens | - |
| retinoblastoma cell | - |
Homo sapiens | - |
| SK-MEL-23 cell | - |
Homo sapiens | - |
| skin | - |
Homo sapiens | - |
| UKRV-Mel-27 cell | - |
Homo sapiens | - |
| Y-79 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphatidylcholine + retinol-[cellular-retinol-binding-protein] | - |
Homo sapiens | 2-acylglycerophosphocholine + retinyl-ester-[cellular-retinol-binding-protein] | - |
? | |
| phosphatidylcholine + retinol-[cellular-retinol-binding-protein] | esterification of all-trans-retinol | Homo sapiens | 2-acylglycerophosphocholine + retinyl-ester-[cellular-retinol-binding-protein] | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| lecithin/retinol acyltransferase | - |
Homo sapiens |
| LRAT | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | expression of LRAT and RPE65 can be modulated by retinoids | additional information |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | the key step of vitamin A metabolism is the esterification of all-trans retinol, catalyzed by lecithin/retinol acyltransferase, LRAT. Vitamin A metabolism in benign and malignant melanocytic skin cells with regard to expression, functional activity of LRAT, RPE65, and cRBP2 and their regulation, overview | Homo sapiens |
| additional information | malignant melanoma cells are able to esterify all-trans retinol and subsequently isomerize all-trans retinyl esters into 11-cis retinol, whereas their benign counterpart melanocytes are not able to catalyze these reactions | Homo sapiens |
| physiological function | activities of LRAT and RPE65 may be important for removal of all-trans retinal which is the substrate for retinoic acid production in skin cells. Decreasing cellular amount of retinoic acid and its precursor molecules might result in a change of gene regulation | Homo sapiens |
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Release 2023.1 (January 2023)
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