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Literature summary for 2.3.1.135 extracted from

  • Piantedosi, R.; Ghyselinck, N.; Blaner, W.S.; Vogel, S.
    Cellular retinol-binding protein type III is needed for retinoid incorporation into milk (2005), J. Biol. Chem., 280, 24286-24292.
    View publication on PubMed
Search for more literature for 2.3.1.135

Activating Compound

Activating Compound Comment Organism Structure
cellular retinol-binding protein CRBP, required for enzyme activity, CRBP-I and CRBP-III each compensate for the absence of the other, specifically in mammary tissue, adipose tissue, muscle, and heart Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information disruption of the CRBP-III gene and generation of CRBPIII-/- mice, method, overview, [cellular retinol-binding protein III]-deficient female mice produce milk with less retinyl ester content, especially retinyl-palmitate, compared to wild-type mice, the expression of CRBP-I is increased in adipose tissue of CRBP-III-/- mice compared to the wild-type mice Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
apo-CRBP-I i.e. apo-[cellular retinol-binding protein I], no inhibition by apo-CRBP-III Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
lecithin + retinol-[cellular retinol-binding protein III] Mus musculus the enzyme is responsible for catalyzing retinyl ester formation from retinol 2-acylglycerophosphocholine + retinyl ester-[cellular retinol-binding protein III]
-
 ?
lecithin + retinol-[cellular retinol-binding protein III] Mus musculus C57/BL6J the enzyme is responsible for catalyzing retinyl ester formation from retinol 2-acylglycerophosphocholine + retinyl ester-[cellular retinol-binding protein III]
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57BL/6J mice
-
Mus musculus C57/BL6J
-
 C57BL/6J mice
-

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue
-
 Mus musculus
-
heart
-
 Mus musculus
-
mammary gland
-
 Mus musculus
-
muscle
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
lecithin + retinol-[cellular retinol-binding protein III] the enzyme is responsible for catalyzing retinyl ester formation from retinol Mus musculus 2-acylglycerophosphocholine + retinyl ester-[cellular retinol-binding protein III]
-
 ?
lecithin + retinol-[cellular retinol-binding protein III] retinol bound to cellular retinol-binding protein III, CRBP-III, is an excellent substrate for lecithin-retinol acyltransferase Mus musculus 2-acylglycerophosphocholine + retinyl ester-[cellular retinol-binding protein III]
-
 ?
lecithin + retinol-[cellular retinol-binding protein III] the enzyme is responsible for catalyzing retinyl ester formation from retinol Mus musculus C57/BL6J 2-acylglycerophosphocholine + retinyl ester-[cellular retinol-binding protein III]
-
 ?
lecithin + retinol-[cellular retinol-binding protein III] retinol bound to cellular retinol-binding protein III, CRBP-III, is an excellent substrate for lecithin-retinol acyltransferase Mus musculus C57/BL6J 2-acylglycerophosphocholine + retinyl ester-[cellular retinol-binding protein III]
-
 ?

Synonyms

Synonyms Comment Organism
lecithin-retinol acyltransferase
-
 Mus musculus
LRAT
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
 assay at Mus musculus