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Literature summary for 2.3.1.135 extracted from
- Differential interaction of lecithin-retinol acyltransferase with cellular retinol binding proteins (1992), Biochemistry, 31, 6748-6755.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Apo-cellular-retinol-binding protein | - |
Rattus norvegicus | |
| additional information | 1% dimethylsulfoxide does not inhibit LRAT activity | Rattus norvegicus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0002 | - |
retinol-[cellular-retinol-binding-protein] | intestinal LRAT, reaction with phosphatidylcholine | Rattus norvegicus |  |
| 0.00024 | - |
retinol-(cellular-retinol-binding protein) type II | intestinal LRAT, reaction with phosphatidylcholine | Rattus norvegicus | |
| 0.00032 | - |
retinol-[cellular-retinol-binding-proteintype II] | liver LRAT, reaction with phosphatidylcholine | Rattus norvegicus | |
| 0.00044 | - |
retinol | liver LRAT, reaction with phosphatidylcholine | Rattus norvegicus | |
| 0.00063 | - |
retinol | intestinal LRAT, reaction with phosphatidylcholine | Rattus norvegicus | |
| 0.00078 | - |
retinol-[cellular-retinol-binding-protein] | liver LRAT, reaction with phosphatidylcholine | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphatidylcholine + all-trans-retinol | Rattus norvegicus | important role in absorption and storage of vitamin A | all-trans-retinyl acyl esters + 2-acylglycerophosphocholine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| intestine | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | little or no ability to transfer acyl groups from lysophosphatidylcholine, phosphatidylethanolamine or phosphatidic acid to retinol-(cellular-retinol-binding protein) | Rattus norvegicus | ? | - |
? | |
| additional information | only fatty acyl group at the sn-1 is transferred | Rattus norvegicus | ? | - |
? | |
| additional information | phosphatidylcholine selective | Rattus norvegicus | ? | - |
? | |
| phosphatidylcholine + all-trans-retinol | - |
Rattus norvegicus | all-trans-retinyl acyl esters + 2-acylglycerophosphocholine | - |
? | |
| phosphatidylcholine + all-trans-retinol | important role in absorption and storage of vitamin A | Rattus norvegicus | all-trans-retinyl acyl esters + 2-acylglycerophosphocholine | - |
? | |
| phosphatidylcholine + retinol-(cellular-retinol-binding protein) type II | - |
Rattus norvegicus | 2-acylglycerophosphocholine + retinyl ester-(cellular-retinol-binding-protein) type II | - |
? | |
| phosphatidylcholine + retinol-(cellular-retinol-binding-protein) | - |
Rattus norvegicus | 2-acylglycerophosphocholine + retinyl ester-(cellular-retinol-binding-protein) | - |
? | |
| phosphatidylcholine + retinol-[cellular-retinol-binding-protein type II] | - |
Rattus norvegicus | 2-acylglycerophosphocholine + retinyl-ester-[cellular-retinol-binding-protein type II] | - |
? | |
| phosphatidylcholine + retinol-[cellular-retinol-binding-protein] | - |
Rattus norvegicus | 2-acylglycerophosphocholine + retinyl-ester-[cellular-retinol-binding-protein] | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
- |
Rattus norvegicus |
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