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Literature summary for 2.3.1.13 extracted from

  • Matsuo, M.; Terai, K.; Kameda, N.; Matsumoto, A.; Kurokawa, Y.; Funase, Y.; Nishikawa, K.; Sugaya, N.; Hiruta, N.; Kishimoto, T.
    Designation of enzyme activity of glycine-N-acyltransferase family genes and depression of glycine-N-acyltransferase in human hepatocellular carcinoma (2012), Biochem. Biophys. Res. Commun., 420, 901-906.
    View publication on PubMed

Application

Application Comment Organism
medicine isoform Glyat expression is suppressed in all hepatocellular carcinomas, but not in other liver diseases. Glyat repression in cancerous cells in the liver is controlled at the transcriptional level Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q6IB77 isoform Glyat
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzoyl-CoA + glycine best substrates are benzoyl-CoA as an acyl donor and glycine as acyl acceptor Homo sapiens CoA + N-benzoylglycine
-
?
benzoyl-CoA + L-glutamine 24% of the rate with glycine and benzoyl-CoA Homo sapiens CoA + N-benzoyl-L-glutamine
-
?

Synonyms

Synonyms Comment Organism
GlyAT
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens isoform Glyat expression is suppressed in all hepatocellular carcinomas, but not in other liver diseases. Glyat repression in cancerous cells in the liver is controlled at the transcriptional level down