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Literature summary for 2.3.1.129 extracted from

  • Peng, D.; Hong, W.; Choudhury, B.P.; Carlson, R.W.; Gu, X.X.
    Moraxella catarrhalis bacterium without endotoxin, a potential vaccine candidate (2005), Infect. Immun., 73, 7569-7577.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
gene lpxA, DNA and amino acid sequence determination, subcloning in Escherichia coli, wild-type and mutant strains expression analysis Moraxella catarrhalis

Protein Variants

Protein Variants Comment Organism
additional information construction and characterization of an isogenic Moraxella catarrhalis lpxA mutant in strain O35E, which is viable despite the complete loss of cell surface lipooligosaccharides, the mutant strain shows significantly decreased toxicity in the Limulus amebocyte lysate assay, reduced resistance to normal human serum, reduced adherence to human epithelial cells, and enhanced clearance in lungs and nasopharynx in a mouse aerosol challenge model, phenotype, overview, the mutant elicits high levels of antibodies with bactericidal activity and provides protection against a challenge with the wild-type strain, thus the null LOS mutant is attenuated and may be a potential vaccine candidate against Moraxella catarrhalis Moraxella catarrhalis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Moraxella catarrhalis the enzyme is responsible for the first step of lipid A biosynthesis ?
-
 ?
additional information Moraxella catarrhalis O35E the enzyme is responsible for the first step of lipid A biosynthesis ?
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 ?

Organism

Organism UniProt Comment Textmining
Moraxella catarrhalis Q3BDJ0 gene lpxA
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Moraxella catarrhalis O35E Q3BDJ0 gene lpxA
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is responsible for the first step of lipid A biosynthesis Moraxella catarrhalis ?
-
 ?
additional information the enzyme is responsible for the first step of lipid A biosynthesis Moraxella catarrhalis O35E ?
-
 ?

Synonyms

Synonyms Comment Organism
LpxA
-
 Moraxella catarrhalis
UDP-N-acetylglucosamine acyltransferase
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 Moraxella catarrhalis