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Literature summary for 2.3.1.129 extracted from
- Crystal structure of UDP-N-acetylglucosamine acyltransferase from Helicobacter pylori (2003), Proteins, 53, 772-774.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| purified recombinant, C-terminally eight-residue-tagged enzyme, X-ray diffraction structure analysis at 2.1 A resolution, modeling of the enzyme complexed with [acyl-carrier protein] | Helicobacter pylori |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| sulfate | 2 ions per asymmetrical unit | Helicobacter pylori |  |
| Tartrate | 1 ions per asymmetrical unit | Helicobacter pylori | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 29855 | - |
3 * 29855, amino acid sequence and crystal structure determination | Helicobacter pylori |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetyl-alpha-D-glucosamine | Helicobacter pylori | first step in lipid A biosynthesis pathway | [acyl-carrier protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Helicobacter pylori | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetyl-alpha-D-glucosamine | - |
Helicobacter pylori | [acyl-carrier protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine | - |
? | |
| (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetyl-alpha-D-glucosamine | first step in lipid A biosynthesis pathway | Helicobacter pylori | [acyl-carrier protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetyl-alpha-D-glucosamine | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | enzyme structure contains a left-handed parallel beta-helix motif | Helicobacter pylori |
| trimer | 3 * 29855, amino acid sequence and crystal structure determination | Helicobacter pylori |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| LpxA | - |
Helicobacter pylori |
| UDP-N-acetylglucosamine acyltransferase | - |
Helicobacter pylori |
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Release 2023.1 (January 2023)
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