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Literature summary for 2.3.1.118 extracted from

  • Winter, H.R.; Unadkat, J.D.
    Identification of cytochrome P450 and arylamine N-acetyltransferase isoforms involved in sulfadiazine metabolism (2005), Drug Metab. Dispos., 33, 969-976.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1
-
Sulfadiazine native enzyme, pH 7.5 Homo sapiens
5.4
-
Sulfadiazine recombinant isoform NAT2*4, pH 7.5 Homo sapiens
5.8
-
Sulfadiazine recombinant isoform NAT1*3, pH 7.5 Homo sapiens
136
-
sulfamethazine recombinant isoform NAT2*4, pH 7.5 Homo sapiens
687
-
p-Aminobenzoic acid recombinant isoform NAT1*3, pH 7.5 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
expression of isiforms NAT1*3 and NAT2*4 in Escherichia coli
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0008
-
substrate sulfamethazine, recombinant isoform NAT2*4, pH 7.5 Homo sapiens
0.0029
-
substrate sulfadiazine, recombinant isoform NAT2*4, pH 7.5 Homo sapiens
0.0064
-
substrate p-aminobenzoic aicd, recombinant isoform NAT1*3, pH 7.5 Homo sapiens
0.0183
-
substrate sulfadiazine, recombinant isoform NAT1*3, pH 7.5 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
p-aminobenzoic acid + acetyl-CoA
-
Homo sapiens N-acetyl-p-aminobenzoic acid + CoA
-
?
sulfadiazine + acetyl-CoA
-
Homo sapiens N-acetyl-sulfadiazine + CoA
-
?
sulfamethazine + acetyl-CoA
-
Homo sapiens N-acetyl-sulfamethazine + CoA
-
?

Synonyms

Synonyms Comment Organism
N-arylamine acetyltransferase
-
Homo sapiens