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Literature summary for 2.3.1.118 extracted from

  • Watanabe, M.; Sofuni, T.; Nohmi, T.
    Involvement of Cys69 residue in the catalytic mechanism of N-hydroxyarylamine O-acetyltransferase of Salmonella typhimurium. Sequence similarity at the amino acid level suggests a common catalytic mechanism of acetyltransferase for S. typhimurium and higher organisms (1992), J. Biol. Chem., 267, 8429-8436.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
cloned and expression of wild type and two mutant enzymes in Escherichia coli XL-1-Blue maxi cells, plasmid pYG122 Salmonella enterica subsp. enterica serovar Typhimurium

Protein Variants

Protein Variants Comment Organism
A69C reduces enzyme activity without affecting stability and mobility on SDS-PAGE Salmonella enterica subsp. enterica serovar Typhimurium
A69R reduces enzyme activity without affecting stability and mobility on SDS-PAGE Salmonella enterica subsp. enterica serovar Typhimurium

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.01
-
acetyl-CoA reaction with 2-hydroxy-amino-6-methyldipyrido[1,2-alpha: 3',2'-d]imidazole as substrate Salmonella enterica subsp. enterica serovar Typhimurium

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Salmonella enterica subsp. enterica serovar Typhimurium 5829
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
32180
-
calculated from nucleotide sequence Salmonella enterica subsp. enterica serovar Typhimurium

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-
Salmonella enterica subsp. enterica serovar Typhimurium
-
derived from strain LT2
-
Salmonella enterica subsp. enterica serovar Typhimurium
-
TA 1538
-
Salmonella enterica subsp. enterica serovar Typhimurium TA 1538
-
TA 1538
-
Salmonella enterica subsp. enterica serovar Typhimurium TA98
-
-
-

Purification (Commentary)

Purification (Comment) Organism
nucleotide sequence Salmonella enterica subsp. enterica serovar Typhimurium

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.001
-
N-acetylation of p-aminobenzoic acid Salmonella enterica subsp. enterica serovar Typhimurium
0.517
-
N-acetylation of 2-aminofluorene Salmonella enterica subsp. enterica serovar Typhimurium
1.31
-
2-hydroxyamino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole as substrate Salmonella enterica subsp. enterica serovar Typhimurium
8.72
-
N-acetylation of isoniazide Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
-
Salmonella enterica subsp. enterica serovar Typhimurium CoA + N-acetoxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
-
?
acetyl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
-
Salmonella enterica subsp. enterica serovar Typhimurium TA 1538 CoA + N-acetoxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
-
?
acetyl-CoA + 2-hydroxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
-
Salmonella enterica subsp. enterica serovar Typhimurium TA98 CoA + N-acetoxy-amino-6-methyldipyrido[1,2-a: 3',2'-d]imidazole
-
?

Subunits

Subunits Comment Organism
monomer
-
Salmonella enterica subsp. enterica serovar Typhimurium

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Salmonella enterica subsp. enterica serovar Typhimurium