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Literature summary for 2.3.1.108 extracted from

  • Kalebic, N.; Martinez, C.; Perlas, E.; Hublitz, P.; Bilbao-Cortes, D.; Fiedorczuk, K.; Andolfo, A.; Heppenstall, P.A.
    Tubulin acetyltransferase alphaTAT1 destabilizes microtubules independently of its acetylation activity (2013), Mol. Cell. Biol., 33, 1114-1123.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.108

Cloned(Commentary)

Cloned (Comment) Organism
-
 Mus musculus

Protein Variants

Protein Variants Comment Organism
G134W/G136W/L139P loss of catalytic activity Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
microtubule colocalization with microtubules Mus musculus 5874
-

Organism

Organism UniProt Comment Textmining
Mus musculus Q8K341
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
acetylation enzyme catalyzes acetylation of multiple lysine residues on itself. Autoacetylation of alphaTAT1 increases its catalytic activity at microtubules Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
cerebellum
-
 Mus musculus
-
ganglion dorsal root ganglion Mus musculus
-
hippocampus
-
 Mus musculus
-
nervous system strongest expression in nervous systems of embryonic and adult mice Mus musculus
-
spinal cord
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + [alpha-TAT1]-L-lysine
-
 Mus musculus CoA + [alpha-TAT1]-N6-acetyl-L-lysine enzyme TAT1 acetylates itself in a regulatory mechanism that is required for effective modification of tubulin. Acetylation of multiple lysine residues on itself ?
acetyl-CoA + [alpha-tubulin]-L-lysine40
-
 Mus musculus CoA + [alpha-tubulin]-N6-acetyl-L-lysine40
-
 ?

Synonyms

Synonyms Comment Organism
alphaTAT1
-
 Mus musculus

General Information

General Information Comment Organism
physiological function alphaTAT1 promotes microtubule destabilization and accelerates microtubule dynamics. This effect persists in an alphaTAT1 mutant with no acetyltransferase activity, suggesting that interaction of alphaTAT1 with microtubules is the critical factor regulating microtubule stability Mus musculus