BRENDA - Enzyme Database
show all sequences of 2.3.1.108

MEC-17 is an alpha-tubulin acetyltransferase

Akella, J.S.; Wloga, D.; Kim, J.; Starostina, N.G.; Lyons-Abbott, S.; Morrissette, N.S.; Dougan, S.T.; Kipreos, E.T.; Gaertig, J.; Nature 467, 218-222 (2010)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expression of GST-tagged Mec-17 in Escherichia coli strain BL21
Mus musculus
MEC-17 sequences are absent from Chlamydomonas reinhardtii, an organism that has alphaTAT activity
Chlamydomonas reinhardtii
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
flagellum
-
Chlamydomonas reinhardtii
-
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
acetyl-CoA + [alpha-tubulin]-L-lysine
Chlamydomonas reinhardtii
acetylation of the epsilon-amino group of Lys40
CoA + [alpha-tubulin]-N6-acetyl-L-lysine
-
-
?
acetyl-CoA + [alpha-tubulin]-L-lysine
Mus musculus
acetylation of the epsilon-amino group of Lys40
CoA + [alpha-tubulin]-N6-acetyl-L-lysine
-
-
?
acetyl-CoA + [alpha-tubulin]-L-lysine
Caenorhabditis elegans
acetylation of the epsilon-amino group of Lys40
CoA + [alpha-tubulin]-N6-acetyl-L-lysine
-
-
?
acetyl-CoA + [alpha-tubulin]-L-lysine
Danio rerio
acetylation of the epsilon-amino group of Lys40
CoA + [alpha-tubulin]-N6-acetyl-L-lysine
-
-
?
acetyl-CoA + [alpha-tubulin]-L-lysine
Tetrahymena thermophila
acetylation of the epsilon-amino group of Lys40, in Tetrahymena, alpha-tubulin is the major if not the only substrate of MEC-17-dependent K acetylation
CoA + [alpha-tubulin]-N6-acetyl-L-lysine
-
-
?
additional information
Caenorhabditis elegans
wild-type adults have a strong signal for acetylated alpha-tubulin in the six touch receptor neurons
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Caenorhabditis elegans
-
-
-
Chlamydomonas reinhardtii
-
-
-
Danio rerio
-
-
-
Mus musculus
-
-
-
Tetrahymena thermophila
-
-
-
Purification (Commentary)
Commentary
Organism
recombinant GST-tagged Mec-17 from Escherichia coli strain BL21 by glutathione affinity chromatography
Mus musculus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
-
Danio rerio
-
neuron
peripheral, acetyl-K40 alpha-tubulin is enriched in cilia and axons of neurons
Danio rerio
-
optic nerve
-
Danio rerio
-
spinal cord
-
Danio rerio
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acetyl-CoA + [alpha-tubulin]-L-lysine
acetylation of the epsilon-amino group of Lys40
720540
Chlamydomonas reinhardtii
CoA + [alpha-tubulin]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [alpha-tubulin]-L-lysine
acetylation of the epsilon-amino group of Lys40
720540
Mus musculus
CoA + [alpha-tubulin]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [alpha-tubulin]-L-lysine
acetylation of the epsilon-amino group of Lys40
720540
Caenorhabditis elegans
CoA + [alpha-tubulin]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [alpha-tubulin]-L-lysine
acetylation of the epsilon-amino group of Lys40
720540
Tetrahymena thermophila
CoA + [alpha-tubulin]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [alpha-tubulin]-L-lysine
acetylation of the epsilon-amino group of Lys40
720540
Danio rerio
CoA + [alpha-tubulin]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [alpha-tubulin]-L-lysine
acetylation of the epsilon-amino group of Lys40, in Tetrahymena, alpha-tubulin is the major if not the only substrate of MEC-17-dependent K acetylation
720540
Tetrahymena thermophila
CoA + [alpha-tubulin]-N6-acetyl-L-lysine
-
-
-
?
additional information
wild-type adults have a strong signal for acetylated alpha-tubulin in the six touch receptor neurons
720540
Caenorhabditis elegans
?
-
-
-
-
additional information
in vitro, MEC-17 exclusively acetylates Lys40 of alpha-tubulin
720540
Caenorhabditis elegans
?
-
-
-
-
additional information
recombinant GST-MEC-17 directly acetylates purified tubulin from the MEC17-KO strain in vitro
720540
Mus musculus
?
-
-
-
-
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
-
assay at
Caenorhabditis elegans
8
-
assay at
Chlamydomonas reinhardtii
8
-
assay at
Danio rerio
8
-
assay at
Mus musculus
8
-
assay at
Tetrahymena thermophila
Cofactor
Cofactor
Commentary
Organism
Structure
acetyl-CoA
-
Chlamydomonas reinhardtii
acetyl-CoA
-
Danio rerio
acetyl-CoA
-
Mus musculus
acetyl-CoA
-
Tetrahymena thermophila
acetyl-CoA
-
Caenorhabditis elegans
Cloned(Commentary) (protein specific)
Commentary
Organism
expression of GST-tagged Mec-17 in Escherichia coli strain BL21
Mus musculus
MEC-17 sequences are absent from Chlamydomonas reinhardtii, an organism that has alphaTAT activity
Chlamydomonas reinhardtii
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
acetyl-CoA
-
Chlamydomonas reinhardtii
acetyl-CoA
-
Danio rerio
acetyl-CoA
-
Mus musculus
acetyl-CoA
-
Tetrahymena thermophila
acetyl-CoA
-
Caenorhabditis elegans
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
flagellum
-
Chlamydomonas reinhardtii
-
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
acetyl-CoA + [alpha-tubulin]-L-lysine
Chlamydomonas reinhardtii
acetylation of the epsilon-amino group of Lys40
CoA + [alpha-tubulin]-N6-acetyl-L-lysine
-
-
?
acetyl-CoA + [alpha-tubulin]-L-lysine
Mus musculus
acetylation of the epsilon-amino group of Lys40
CoA + [alpha-tubulin]-N6-acetyl-L-lysine
-
-
?
acetyl-CoA + [alpha-tubulin]-L-lysine
Caenorhabditis elegans
acetylation of the epsilon-amino group of Lys40
CoA + [alpha-tubulin]-N6-acetyl-L-lysine
-
-
?
acetyl-CoA + [alpha-tubulin]-L-lysine
Danio rerio
acetylation of the epsilon-amino group of Lys40
CoA + [alpha-tubulin]-N6-acetyl-L-lysine
-
-
?
acetyl-CoA + [alpha-tubulin]-L-lysine
Tetrahymena thermophila
acetylation of the epsilon-amino group of Lys40, in Tetrahymena, alpha-tubulin is the major if not the only substrate of MEC-17-dependent K acetylation
CoA + [alpha-tubulin]-N6-acetyl-L-lysine
-
-
?
additional information
Caenorhabditis elegans
wild-type adults have a strong signal for acetylated alpha-tubulin in the six touch receptor neurons
?
-
-
-
Purification (Commentary) (protein specific)
Commentary
Organism
recombinant GST-tagged Mec-17 from Escherichia coli strain BL21 by glutathione affinity chromatography
Mus musculus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
-
Danio rerio
-
neuron
peripheral, acetyl-K40 alpha-tubulin is enriched in cilia and axons of neurons
Danio rerio
-
optic nerve
-
Danio rerio
-
spinal cord
-
Danio rerio
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acetyl-CoA + [alpha-tubulin]-L-lysine
acetylation of the epsilon-amino group of Lys40
720540
Chlamydomonas reinhardtii
CoA + [alpha-tubulin]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [alpha-tubulin]-L-lysine
acetylation of the epsilon-amino group of Lys40
720540
Mus musculus
CoA + [alpha-tubulin]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [alpha-tubulin]-L-lysine
acetylation of the epsilon-amino group of Lys40
720540
Caenorhabditis elegans
CoA + [alpha-tubulin]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [alpha-tubulin]-L-lysine
acetylation of the epsilon-amino group of Lys40
720540
Tetrahymena thermophila
CoA + [alpha-tubulin]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [alpha-tubulin]-L-lysine
acetylation of the epsilon-amino group of Lys40
720540
Danio rerio
CoA + [alpha-tubulin]-N6-acetyl-L-lysine
-
-
-
?
acetyl-CoA + [alpha-tubulin]-L-lysine
acetylation of the epsilon-amino group of Lys40, in Tetrahymena, alpha-tubulin is the major if not the only substrate of MEC-17-dependent K acetylation
720540
Tetrahymena thermophila
CoA + [alpha-tubulin]-N6-acetyl-L-lysine
-
-
-
?
additional information
wild-type adults have a strong signal for acetylated alpha-tubulin in the six touch receptor neurons
720540
Caenorhabditis elegans
?
-
-
-
-
additional information
in vitro, MEC-17 exclusively acetylates Lys40 of alpha-tubulin
720540
Caenorhabditis elegans
?
-
-
-
-
additional information
recombinant GST-MEC-17 directly acetylates purified tubulin from the MEC17-KO strain in vitro
720540
Mus musculus
?
-
-
-
-
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
-
assay at
Caenorhabditis elegans
8
-
assay at
Chlamydomonas reinhardtii
8
-
assay at
Danio rerio
8
-
assay at
Mus musculus
8
-
assay at
Tetrahymena thermophila
Expression
Organism
Commentary
Expression
Tetrahymena thermophila
construction of a Mec-17 disruption mutant. The MEC-17-KO Tetrahymena cells have a normal growth rate, but theMEC-17-KOcells grow more slowly than wild type on medium with the microtubule depolymerizing compound oryzalin. Conversely, the MEC-17 KO cells grew faster than wild-type cells in medium with paclitaxel, a microtubule-stabilizing drug. This drug phenotype is consistent with an increase in dynamics of microtubules in MEC17-KO cells
additional information
General Information
General Information
Commentary
Organism
evolution
MEC-17 is related to the Gcn5 histone acetyltransferases
Caenorhabditis elegans
evolution
MEC-17 is related to the Gcn5 histone acetyltransferases
Danio rerio
evolution
MEC-17 is related to the Gcn5 histone acetyltransferases
Mus musculus
evolution
MEC-17 is related to the Gcn5 histone acetyltransferases
Tetrahymena thermophila
malfunction
MEC-12 is the only alpha-tubulin with K40, and mec-12(e1607) probable null allele worms have greatly reduced touch responses. Intergration of single transgenes encoding MEC-12 with either wild-type K40 or K40R or K40Q substitutions into the mec-12(e1607)mutant using Mos1 transposon excision repair restores the levels of touch response to 80% of wild type level,whereas animals with either MEC-12-K40R or MEC-12-K40Q show reduced touch response, overview
Caenorhabditis elegans
malfunction
zebrafish embryos depleted in MEC-17 show a dramatic loss of acetyl-K40 in neurons but not in cilia. Depletion of MEC-17 in zebrafish, by injection with random sequence morpholinos or 5-bp mismatched morpholinos, produces phenotypes consistent with neuromuscular defects
Danio rerio
malfunction
disruption of the Tetrahymena MEC-17 gene, resulting in a marked loss of acetyl-K40 in Tetrahymena cells, phenocopies the K40R alpha-tubulin mutation and makes microtubules more labile. Overexpression of GFP-Mec17p in Tetrahymena greatly increases acetylation of microtubules
Tetrahymena thermophila
additional information
MEC-17 sequences are absent from Chlamydomonas reinhardtii, an organism that has alphaTAT activity
Chlamydomonas reinhardtii
physiological function
MEC-17 is required for the function of touch receptor neurons in Caenorhabditis elegans and acts as a K40-specific acetyltransferase for alpha-tubulin. W06B11.1 os also required for acetylation of K40 and contribute to touch sensation
Caenorhabditis elegans
physiological function
the K40 residue of alpha-tubulin is not required for survival in protists, such as Chlamydomonas
Chlamydomonas reinhardtii
physiological function
the K40 residue of alpha-tubulin is important in vertebrates, acetyl-K40-carrying microtubules are abundant in the nervous system, including the brain, optical nerves, spinal cord, and axons of peripheral nerves. MEC-17 is required for K40 acetylation in zebrafish and normal embryonic development
Danio rerio
physiological function
the K40 residue of alpha-tubulin is important in vertebrates, MEC-17 controls the levels of microtubule acetylation in mammalian cells
Mus musculus
physiological function
the K40 residue of alpha-tubulin is not required for survival in protists, such as Tetrahymena
Tetrahymena thermophila
General Information (protein specific)
General Information
Commentary
Organism
evolution
MEC-17 is related to the Gcn5 histone acetyltransferases
Caenorhabditis elegans
evolution
MEC-17 is related to the Gcn5 histone acetyltransferases
Danio rerio
evolution
MEC-17 is related to the Gcn5 histone acetyltransferases
Mus musculus
evolution
MEC-17 is related to the Gcn5 histone acetyltransferases
Tetrahymena thermophila
malfunction
MEC-12 is the only alpha-tubulin with K40, and mec-12(e1607) probable null allele worms have greatly reduced touch responses. Intergration of single transgenes encoding MEC-12 with either wild-type K40 or K40R or K40Q substitutions into the mec-12(e1607)mutant using Mos1 transposon excision repair restores the levels of touch response to 80% of wild type level,whereas animals with either MEC-12-K40R or MEC-12-K40Q show reduced touch response, overview
Caenorhabditis elegans
malfunction
zebrafish embryos depleted in MEC-17 show a dramatic loss of acetyl-K40 in neurons but not in cilia. Depletion of MEC-17 in zebrafish, by injection with random sequence morpholinos or 5-bp mismatched morpholinos, produces phenotypes consistent with neuromuscular defects
Danio rerio
malfunction
disruption of the Tetrahymena MEC-17 gene, resulting in a marked loss of acetyl-K40 in Tetrahymena cells, phenocopies the K40R alpha-tubulin mutation and makes microtubules more labile. Overexpression of GFP-Mec17p in Tetrahymena greatly increases acetylation of microtubules
Tetrahymena thermophila
additional information
MEC-17 sequences are absent from Chlamydomonas reinhardtii, an organism that has alphaTAT activity
Chlamydomonas reinhardtii
physiological function
MEC-17 is required for the function of touch receptor neurons in Caenorhabditis elegans and acts as a K40-specific acetyltransferase for alpha-tubulin. W06B11.1 os also required for acetylation of K40 and contribute to touch sensation
Caenorhabditis elegans
physiological function
the K40 residue of alpha-tubulin is not required for survival in protists, such as Chlamydomonas
Chlamydomonas reinhardtii
physiological function
the K40 residue of alpha-tubulin is important in vertebrates, acetyl-K40-carrying microtubules are abundant in the nervous system, including the brain, optical nerves, spinal cord, and axons of peripheral nerves. MEC-17 is required for K40 acetylation in zebrafish and normal embryonic development
Danio rerio
physiological function
the K40 residue of alpha-tubulin is important in vertebrates, MEC-17 controls the levels of microtubule acetylation in mammalian cells
Mus musculus
physiological function
the K40 residue of alpha-tubulin is not required for survival in protists, such as Tetrahymena
Tetrahymena thermophila
Expression (protein specific)
Organism
Commentary
Expression
Tetrahymena thermophila
construction of a Mec-17 disruption mutant. The MEC-17-KO Tetrahymena cells have a normal growth rate, but theMEC-17-KOcells grow more slowly than wild type on medium with the microtubule depolymerizing compound oryzalin. Conversely, the MEC-17 KO cells grew faster than wild-type cells in medium with paclitaxel, a microtubule-stabilizing drug. This drug phenotype is consistent with an increase in dynamics of microtubules in MEC17-KO cells
additional information
Other publictions for EC 2.3.1.108
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
736728
Nakakura
Intracellular localization of ...
Rattus norvegicus
Med. Mol. Morphol.
49
133-143
2016
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735638
Yuzawa
Structural basis of cofactor-m ...
Homo sapiens
Biochem. J.
467
103-113
2015
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735908
Neumann
Loss of MEC-17 leads to microt ...
Caenorhabditis elegans
Cell Rep.
6
93-103
2014
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735916
Szyk
Molecular basis for age-depend ...
Homo sapiens
Cell
157
1405-1415
2014
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736637
Davenport
Structural and functional char ...
Homo sapiens
J. Mol. Biol.
426
2605-2616
2014
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33
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20
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19
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736778
Howes
Effects of tubulin acetylation ...
Homo sapiens
Mol. Biol. Cell
25
257-266
2014
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736872
Wang
Microtubule acetylation amplif ...
Mus musculus
Nat. Commun.
5
3479
2014
1
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735631
Yang
Regulation of adipogenesis by ...
Mus musculus
Biochem. J.
449
605-612
2013
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736795
Kalebic
Tubulin acetyltransferase alph ...
Mus musculus
Mol. Cell. Biol.
33
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