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Literature summary for 2.3.1.108 extracted from

  • Topalidou, I.; Keller, C.; Kalebic, N.; Nguyen, K.C.; Somhegyi, H.; Politi, K.A.; Heppenstall, P.; Hall, D.H.; Chalfie, M.
    Genetically separable functions of the MEC-17 tubulin acetyltransferase affect microtubule organization (2012), Curr. Biol., 22, 1057-1065.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + [alpha-tubulin]-L-lysine Caenorhabditis elegans
-
CoA + [alpha-tubulin]-N6-acetyl-L-lysine
-
?

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + [alpha-tubulin]-L-lysine
-
Caenorhabditis elegans CoA + [alpha-tubulin]-N6-acetyl-L-lysine
-
?

Synonyms

Synonyms Comment Organism
alpha-TAT
-
Caenorhabditis elegans
alpha-tubulin acetyltransferase
-
Caenorhabditis elegans
Mec-17
-
Caenorhabditis elegans
tubulin acetyltransferase
-
Caenorhabditis elegans

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
Caenorhabditis elegans

General Information

General Information Comment Organism
malfunction touch receptor neurons in mec-17 but not atat-2 mutants exhibit morphological defects, phenotype, overview. Both mec-17(ok2109) and mec-17(u265) produced an increase in the length of the touch receptor neuron processes, effects on touch receptor neuron microtubule organization and structure, overview. Enzymatically inactive MEC-17 mutants rescue some of the mec-17 phenotypes, the function of mec-17 is protein-dependent Caenorhabditis elegans
physiological function the enzymatic activity of the alpha-tubulin acetyltransferase MEC-17 allows the production of 15-p microtubules in the touch receptor neurons microtubules, specific role for alpha-TAT in the formation of microtubules and in the production of higher order microtubules arrays. The alpha-TAT protein has functions that require acetyltransferase activity, such as the determination of protofilament number, and others that do not, e.g. presence of internal microtubule structures. Mec-17 and atat-2 are needed for touch sensitivity and MEC-12 acetylation Caenorhabditis elegans