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Literature summary for 2.3.1.107 extracted from
- Purification and characterization of acetylcoenzyme A: deacetylvindoline 4-O-acetyltransferase from Catharanthus roseus (1990), Arch. Biochem. Biophys., 279, 370-376.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| CoA | 0.037 mM, 50% inhibition | Catharanthus roseus |  |
| secologanin | 0.5 mM, 25% inhibition | Catharanthus roseus | |
| tabersonine | 0.045 mM, 50% inhibition | Catharanthus roseus | |
| tryptamine | 0.5 mM, 28% inhibition | Catharanthus roseus | |
| vindoline | 0.5 mM, 40% inhibition | Catharanthus roseus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0013 | - |
deacetylvindoline | - |
Catharanthus roseus | |
| 0.0065 | - |
acetyl-CoA | - |
Catharanthus roseus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + 17-O-deacetylvindoline | Catharanthus roseus | the enzyme catalyzes the final step in the biosynthesis of vindoline | CoA + vindoline | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Catharanthus roseus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Catharanthus roseus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| leaf | - |
Catharanthus roseus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Catharanthus roseus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + 17-O-deacetylvindoline | - |
Catharanthus roseus | CoA + vindoline | - |
? | |
| acetyl-CoA + 17-O-deacetylvindoline | the enzyme catalyzes the final step in the biosynthesis of vindoline | Catharanthus roseus | CoA + vindoline | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 9 | - |
Catharanthus roseus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | 11 | activity increases from pH 5.5 to 7 and decreases rapidly between pH 9 and 11 | Catharanthus roseus |
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Release 2023.1 (January 2023)
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