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show all sequences of 2.3.1.105

The potential for platelet-activating factor synthesis in brain: properties of cholinephosphotransferase and 1-alkyl-sn-glycero-3-phosphate acetyltransferase in microsomal fractions of immature rabbit cerebral cortex

Baker, R.R.; Chang, H.Y.; Biochim. Biophys. Acta 1170, 157-164 (1993)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
1-alkyl-sn-glycero-3-phosphocholine
small increase of activity
Oryctolagus cuniculus
Inhibitors
Inhibitors
Commentary
Organism
Structure
dithiothreitol
-
Oryctolagus cuniculus
additional information
not inhibited by 1-alkyl-sn-glycero-3-phosphocholine, 1-alkyl-sn-glycero-3-phosphocholine
Oryctolagus cuniculus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.11
-
acetyl-CoA
apparent Km for subcellular fraction R
Oryctolagus cuniculus
0.137
-
acetyl-CoA
apparent Km for subcellular fraction P3
Oryctolagus cuniculus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cell body
brain
Oryctolagus cuniculus
44297
-
microsome
-
Oryctolagus cuniculus
-
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Na+
activity appears maximal in the presence of NaF
Oryctolagus cuniculus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
acetyl-CoA + 1-alkyl-sn-glycero-3-phosphate
Oryctolagus cuniculus
-
CoA + 1-alkyl-2-acetyl-sn-glycero-3-phosphate
-
Oryctolagus cuniculus
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Oryctolagus cuniculus
-
-
-
Purification (Commentary)
Commentary
Organism
isolation of four subcellular fractions: S, R and P3 from cerebral cortices and P from nerve cell bodies
Oryctolagus cuniculus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
cerebral cortex
-
Oryctolagus cuniculus
-
nerve
brain
Oryctolagus cuniculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acetyl-CoA + 1-alkyl-sn-glycero-3-phosphate
-
486105
Oryctolagus cuniculus
CoA + 1-alkyl-2-acetyl-sn-glycero-3-phosphate
-
486105
Oryctolagus cuniculus
?
pH Range
pH Minimum
pH Maximum
Commentary
Organism
8
9
subcellular fractions R and P3
Oryctolagus cuniculus
8.4
9
subcellular fractions P
Oryctolagus cuniculus
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
1-alkyl-sn-glycero-3-phosphocholine
small increase of activity
Oryctolagus cuniculus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
dithiothreitol
-
Oryctolagus cuniculus
additional information
not inhibited by 1-alkyl-sn-glycero-3-phosphocholine, 1-alkyl-sn-glycero-3-phosphocholine
Oryctolagus cuniculus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.11
-
acetyl-CoA
apparent Km for subcellular fraction R
Oryctolagus cuniculus
0.137
-
acetyl-CoA
apparent Km for subcellular fraction P3
Oryctolagus cuniculus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cell body
brain
Oryctolagus cuniculus
44297
-
microsome
-
Oryctolagus cuniculus
-
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Na+
activity appears maximal in the presence of NaF
Oryctolagus cuniculus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
acetyl-CoA + 1-alkyl-sn-glycero-3-phosphate
Oryctolagus cuniculus
-
CoA + 1-alkyl-2-acetyl-sn-glycero-3-phosphate
-
Oryctolagus cuniculus
?
Purification (Commentary) (protein specific)
Commentary
Organism
isolation of four subcellular fractions: S, R and P3 from cerebral cortices and P from nerve cell bodies
Oryctolagus cuniculus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
cerebral cortex
-
Oryctolagus cuniculus
-
nerve
brain
Oryctolagus cuniculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acetyl-CoA + 1-alkyl-sn-glycero-3-phosphate
-
486105
Oryctolagus cuniculus
CoA + 1-alkyl-2-acetyl-sn-glycero-3-phosphate
-
486105
Oryctolagus cuniculus
?
pH Range (protein specific)
pH Minimum
pH Maximum
Commentary
Organism
8
9
subcellular fractions R and P3
Oryctolagus cuniculus
8.4
9
subcellular fractions P
Oryctolagus cuniculus
Other publictions for EC 2.3.1.105
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
660411
Nomikos
Application of a TCA-precipita ...
Homo sapiens
Prostaglandins
73
123-140
2004
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
486104
Baker
MgATP inhibits the synthesis o ...
Oryctolagus cuniculus
Biochim. Biophys. Acta
1213
27-33
1994
3
-
-
-
-
-
10
-
1
-
-
1
-
1
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
10
-
-
1
-
-
1
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
486105
Baker
The potential for platelet-act ...
Oryctolagus cuniculus
Biochim. Biophys. Acta
1170
157-164
1993
1
-
-
-
-
-
2
2
2
1
-
1
-
1
-
-
1
-
-
2
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
2
-
2
2
1
-
1
-
-
-
1
-
2
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
486103
Lee
A new de novo pathway for the ...
Rattus norvegicus
J. Biol. Chem.
261
5373-5377
1986
-
-
-
-
-
-
1
1
1
1
-
1
-
2
-
-
-
-
-
7
-
-
2
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
1
1
-
1
-
-
-
-
-
7
-
-
2
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-