Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CoA | 50% activity reduction at 2.5 mM | Escherichia coli | |
L-arginine | 50% activity reduction at 2 mM | Escherichia coli | |
N-acetyl-L-glutamate | 50% activity reduction at 25 mM | Escherichia coli |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.7 | - |
acetyl-CoA | pH and temperature not specified in the publication | Rattus norvegicus | |
1 | - |
L-glutamate | pH and temperature not specified in the publication | Rattus norvegicus | |
4.4 | - |
acetyl-CoA | pH and temperature not specified in the publication | Homo sapiens | |
8.1 | - |
L-glutamate | pH and temperature not specified in the publication | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
190000 | - |
gel filtration | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + L-glutamate | Escherichia coli | - |
CoA + N-acetyl-L-glutamate | - |
? | |
acetyl-CoA + L-glutamate | Homo sapiens | - |
CoA + N-acetyl-L-glutamate | - |
? | |
acetyl-CoA + L-glutamate | Rattus norvegicus | - |
CoA + N-acetyl-L-glutamate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + L-glutamate | - |
Escherichia coli | CoA + N-acetyl-L-glutamate | - |
? | |
acetyl-CoA + L-glutamate | - |
Homo sapiens | CoA + N-acetyl-L-glutamate | - |
? | |
acetyl-CoA + L-glutamate | - |
Rattus norvegicus | CoA + N-acetyl-L-glutamate | - |
? | |
additional information | the enzyme has little activity with glutamine (5.0%) and glycine (2.9%) and no acetylation of other amino acids (less than 1.0%) as well as low activity with propionyl-CoA (4.3%) and no activity with other acyl-CoA derivatives | Escherichia coli | ? | - |
? | |
additional information | the enzyme has little activity with glutamine (5.0%) and glycine (2.9%) and no acetylation of other amino acids (less than 1.0%) as well as low activity with propionyl-CoA (4.3%) and no activity with other acyl-CoA derivatives | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
N-acetyl-L-glutamate synthase | - |
Escherichia coli |
N-acetyl-L-glutamate synthase | - |
Homo sapiens |
N-acetyl-L-glutamate synthase | - |
Rattus norvegicus |
NAGS | - |
Escherichia coli |
NAGS | - |
Homo sapiens |
NAGS | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
2 | - |
pH and temperature not specified in the publication | Escherichia coli | L-arginine | |
2.5 | - |
pH and temperature not specified in the publication | Escherichia coli | CoA | |
25 | - |
pH and temperature not specified in the publication | Escherichia coli | N-acetyl-L-glutamate |