Activating Compound | Comment | Organism | Structure |
---|---|---|---|
L-arginine | - |
Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21 AI cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-methylcrotonyl-CoA | about 45% residual activity at 2.5 mM | Homo sapiens | |
butyryl-CoA | about 30% residual activity at 2.5 mM | Homo sapiens | |
glutaryl-CoA | about 50% residual activity at 2.5 mM | Homo sapiens | |
isobutyryl-CoA | about 45% residual activity at 2.5 mM | Homo sapiens | |
isovaleryl-CoA | about 50% residual activity at 2.5 mM | Homo sapiens | |
methylmalonyl-CoA | about 40% residual activity at 2.5 mM | Homo sapiens | |
propionyl-CoA | about 20% residual activity at 2.5 mM | Homo sapiens | |
succinyl-CoA | about 60% residual activity at 2.5 mM | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.3 | - |
acetyl-CoA | at pH 8.5 and 30°C | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + L-glutamate | Homo sapiens | - |
CoA + N-acetyl-L-glutamate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + L-glutamate | - |
Homo sapiens | CoA + N-acetyl-L-glutamate | - |
? | |
butyryl-CoA + L-glutamate | low activity compared to acetyl-CoA | Homo sapiens | CoA + N-butyryl-L-glutamate | - |
? | |
additional information | no activity with isobutyryl-CoA, isovaleryl-CoA, 3-methylcrotonyl-CoA, methylmalonyl-CoA, succinyl-CoA, and glutaryl-CoA | Homo sapiens | ? | - |
? | |
propionyl-CoA + L-glutamate | low activity compared to acetyl-CoA | Homo sapiens | CoA + N-propionyl-L-glutamate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
N-acetylglutamate synthase | - |
Homo sapiens |
NAGS | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
1.3 | - |
butyryl-CoA | at pH 8.5 and 30°C | Homo sapiens | |
1.9 | - |
isovaleryl-CoA | at pH 8.5 and 30°C | Homo sapiens |