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Literature summary for 2.3.1.1 extracted from

  • Caldovic, L.; Morizono, H.; Yu, X.; Thompson, M.; Shi, D.; Gallegos, R.; Allewell, N.M.; Malamy, M.H.; Tuchman, M.
    Identification, cloning and expression of the mouse N-acetylglutamate synthase gene (2002), Biochem. J., 364, 825-831.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.1

Activating Compound

Activating Compound Comment Organism Structure
arginine 1 mM, 2-6fold activation of recombinant enzyme Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + L-glutamate Mus musculus first enzyme in urea cycle CoA + N-acetyl-L-glutamate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q8R4H7
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme, Ni2+-affinity column Mus musculus

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.346
-
 mature recombinant enzyme in the absence of arginine Mus musculus
0.803
-
 mature recombinant enzyme in the presence of 1 mM arginine Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + L-glutamate
-
 Mus musculus CoA + N-acetyl-L-glutamate
-
 ?
acetyl-CoA + L-glutamate first enzyme in urea cycle Mus musculus CoA + N-acetyl-L-glutamate
-
 ?