BRENDA - Enzyme Database show
show all sequences of 2.3.1.1

Subcellular localization and properties of N-acetylglutamate synthase in rat small intestinal mucosa

Uchiyama, C.; Mori, M.; Tatibana, M.; J. Biochem. 89, 1777-1786 (1981)

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
arginine
1 mM, 2-6fold activation in mitochondria, 1.6fold activation of partially purified enzyme
Rattus norvegicus
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.8
-
acetyl-CoA
-
Rattus norvegicus
2.5
-
L-glutamate
-
Rattus norvegicus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
acetyl-CoA + L-glutamate
Rattus norvegicus
enzyme activates carbamoyl-phosphate synthase ammonia in small intestine mucosa, to allow citrulline synthesis in the tissue
CoA + N-acetyl-L-glutamate
-
Rattus norvegicus
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Rattus norvegicus
-
-
-
Purification (Commentary)
Commentary
Organism
ammonium sulfate, hydroxyapatite
Rattus norvegicus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
small intestine
little activity in muscle layer and serosa; mucosa
Rattus norvegicus
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
0.00000017 mmol N-acetylglutamate/min/g mucosa
Rattus norvegicus
31.6
-
-
Rattus norvegicus
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acetyl-CoA + glycine
-
486068
Rattus norvegicus
CoA + acetylaminoacetate
-
486068
Rattus norvegicus
-
acetyl-CoA + L-aspartate
3.0% of activity with L-glutamate
486068
Rattus norvegicus
CoA + N-acetyl-L-aspartate
-
486068
Rattus norvegicus
?
acetyl-CoA + L-glutamate
-
486068
Rattus norvegicus
CoA + N-acetyl-L-glutamate
-
486068
Rattus norvegicus
?
acetyl-CoA + L-glutamate
enzyme activates carbamoyl-phosphate synthase ammonia in small intestine mucosa, to allow citrulline synthesis in the tissue
486068
Rattus norvegicus
CoA + N-acetyl-L-glutamate
-
486068
Rattus norvegicus
?
propionyl-CoA + L-glutamate
-
486068
Rattus norvegicus
CoA + N-propionyl-L-glutamate
-
486068
Rattus norvegicus
-
Temperature Stability [°C]
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
60
-
5 min, complete loss of activity
Rattus norvegicus
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8.5
-
-
Rattus norvegicus
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
arginine
1 mM, 2-6fold activation in mitochondria, 1.6fold activation of partially purified enzyme
Rattus norvegicus
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.8
-
acetyl-CoA
-
Rattus norvegicus
2.5
-
L-glutamate
-
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
acetyl-CoA + L-glutamate
Rattus norvegicus
enzyme activates carbamoyl-phosphate synthase ammonia in small intestine mucosa, to allow citrulline synthesis in the tissue
CoA + N-acetyl-L-glutamate
-
Rattus norvegicus
?
Purification (Commentary) (protein specific)
Commentary
Organism
ammonium sulfate, hydroxyapatite
Rattus norvegicus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
small intestine
little activity in muscle layer and serosa; mucosa
Rattus norvegicus
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
0.00000017 mmol N-acetylglutamate/min/g mucosa
Rattus norvegicus
31.6
-
-
Rattus norvegicus
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
acetyl-CoA + glycine
-
486068
Rattus norvegicus
CoA + acetylaminoacetate
-
486068
Rattus norvegicus
-
acetyl-CoA + L-aspartate
3.0% of activity with L-glutamate
486068
Rattus norvegicus
CoA + N-acetyl-L-aspartate
-
486068
Rattus norvegicus
?
acetyl-CoA + L-glutamate
-
486068
Rattus norvegicus
CoA + N-acetyl-L-glutamate
-
486068
Rattus norvegicus
?
acetyl-CoA + L-glutamate
enzyme activates carbamoyl-phosphate synthase ammonia in small intestine mucosa, to allow citrulline synthesis in the tissue
486068
Rattus norvegicus
CoA + N-acetyl-L-glutamate
-
486068
Rattus norvegicus
?
propionyl-CoA + L-glutamate
-
486068
Rattus norvegicus
CoA + N-propionyl-L-glutamate
-
486068
Rattus norvegicus
-
Temperature Stability [°C] (protein specific)
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
60
-
5 min, complete loss of activity
Rattus norvegicus
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8.5
-
-
Rattus norvegicus
Other publictions for EC 2.3.1.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
735406
Zhao
Structures of the N-acetyltran ...
Xylella fastidiosa, Xylella fastidiosa ATCC 35881D
Acta Crystallogr. Sect. F
71
86-95
2015
-
-
1
1
-
-
-
-
-
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2
5
-
6
-
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1
-
-
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-
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5
3
1
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-
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1
-
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1
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-
2
1
2
-
-
-
-
-
-
-
-
3
5
-
-
-
2
-
-
-
-
5
3
1
-
-
-
1
-
-
-
-
-
-
-
-
-
736269
Shi
The N-acetylglutamate synthase ...
Escherichia coli, Homo sapiens, Rattus norvegicus
Int. J. Mol. Sci.
16
13004-13022
2015
-
-
-
-
-
-
3
4
-
-
1
3
-
5
-
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-
2
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5
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3
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3
3
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4
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1
3
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2
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
735706
Dercksen
Inhibition of N-acetylglutamat ...
Homo sapiens
Biochim. Biophys. Acta
1842
2510-2516
2014
1
-
1
-
-
-
8
1
-
-
-
1
-
2
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
2
-
-
1
-
1
-
-
-
-
-
8
2
1
-
-
-
1
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
737139
Caldovic
Expression pattern and biochem ...
Danio rerio
PLoS ONE
9
e85597
2014
-
-
1
-
-
-
1
4
-
-
4
1
-
3
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
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-
-
1
-
-
-
-
-
1
-
4
-
-
4
1
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
1
1
1
1
-
-
735596
Zhao
Structure of N-acetyl-L-glutam ...
Maricaulis maris
Biochem. Biophys. Res. Commun.
437
585-590
2013
1
-
1
1
5
-
-
-
-
-
-
2
-
4
-
-
1
-
-
-
2
-
2
-
-
-
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-
-
-
-
-
-
-
-
1
-
1
-
1
5
-
-
-
-
-
-
-
-
2
-
-
-
1
-
-
2
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
735851
Petri
A novel type of N-acetylglutam ...
Corynebacterium glutamicum, Corynebacterium glutamicum ATCC 13032
BMC Genomics
14
713
2013
-
-
1
-
1
-
-
-
-
-
1
4
-
5
-
-
-
-
-
-
-
-
6
1
-
-
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-
-
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-
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2
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-
1
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2
4
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6
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
737116
Zhao
Crystal structure of the N-ace ...
Homo sapiens
PLoS ONE
8
e70369
2013
1
-
1
1
4
-
-
1
1
-
2
3
-
5
-
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1
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4
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4
2
1
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1
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1
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2
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2
7
-
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1
1
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2
3
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2
-
-
4
-
4
2
1
-
-
-
1
-
-
-
-
2
3
-
-
-
718556
Geng
Reduced expression of intestin ...
Sus scrofa
Amino Acids
40
1513-1522
2011
-
-
1
-
-
-
-
-
-
-
2
-
-
6
-
-
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-
-
1
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1
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1
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2
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1
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1
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-
-
-
-
-
-
1
-
-
1
-
-
719937
Nissim
Down-regulation of hepatic ure ...
Rattus norvegicus
J. Biol. Chem.
286
22055-22068
2011
-
-
-
-
-
-
3
2
-
-
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2
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1
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1
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3
3
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2
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1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
720845
Shi
A novel N-acetylglutamate synt ...
Homo sapiens, Maricaulis maris
PLoS ONE
6
e28825
2011
-
-
-
2
-
-
2
-
-
-
-
-
-
8
-
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2
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2
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2
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2
-
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-
-
-
-
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-
-
-
703712
Sancho-Vaello
Mechanism of arginine regulati ...
Pseudomonas aeruginosa
FEBS Lett.
583
202-206
2009
-
-
1
-
4
-
3
20
-
-
-
-
-
3
-
-
1
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-
5
-
1
-
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-
-
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-
-
11
-
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1
-
-
4
-
-
3
11
20
-
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-
-
1
-
-
5
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
704614
Min
Mechanism of allosteric inhibi ...
Neisseria gonorrhoeae
J. Biol. Chem.
284
4873-4880
2009
-
-
1
1
-
-
1
4
-
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1
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-
2
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1
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1
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1
1
1
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1
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1
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1
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1
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1
1
-
4
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1
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1
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1
-
1
1
1
-
-
-
1
-
-
-
-
1
1
-
-
-
704876
Kalamaki
Over-expression of a tomato N- ...
Solanum lycopersicum
J. Exp. Bot.
60
1859-1871
2009
-
-
1
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1
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6
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7
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1
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1
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7
-
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-
-
-
-
-
-
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-
2
-
-
2
-
-
685805
Haskins
Inversion of allosteric effect ...
Arabidopsis thaliana, Danio rerio, Escherichia coli, Maricaulis maris, Mus musculus, Pseudomonas aeruginosa, Takifugu rubripes, Xanthomonas campestris, Xenopus laevis, Xenopus tropicalis
BMC Biochem.
9
24
2008
3
1
10
-
8
-
7
-
-
-
-
1
-
23
-
-
9
-
-
-
35
-
2
-
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-
-
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-
1
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3
1
10
1
-
8
-
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7
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1
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9
-
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35
-
2
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-
-
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-
-
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-
686830
Altarescu
Polar Body-Based Preimplantati ...
Homo sapiens
Fetal. Diagn. Ther.
24
170-176
2008
-
1
-
-
-
-
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690259
Davies
Structure of a putative acetyl ...
Pseudomonas aeruginosa
Acta Crystallogr. Sect. F
64
338-342
2008
-
-
1
1
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-
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2
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1
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1
1
1
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2
1
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-
703696
Sancho-Vaello
Site-directed mutagenesis stud ...
Pseudomonas aeruginosa
FEBS Lett.
582
1081-1086
2008
-
-
1
-
11
-
1
22
-
-
1
-
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4
-
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1
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1
1
-
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1
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11
-
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1
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22
-
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1
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1
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1
1
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-
-
-
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1
1
-
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-
704460
Shi
The crystal structure of N-ace ...
Neisseria gonorrhoeae
J. Biol. Chem.
283
7176-7184
2008
-
-
1
1
3
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
1
-
1
1
1
-
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1
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1
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1
3
-
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1
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1
-
1
1
1
-
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-
1
-
-
-
-
-
-
-
-
-
672793
Qu
A novel bifunctional N-acetylg ...
Xanthomonas campestris
BMC Biochem.
8
4
2007
-
1
1
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2
2
-
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6
-
-
1
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1
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1
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1
1
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1
1
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2
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1
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1
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1
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1
1
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673199
Kim
Functional characterization of ...
Fusarium graminearum
Curr. Genet.
51
99-108
2007
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4
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7
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661651
Haas
N-acetylglutamate synthetase o ...
Pseudomonas aeruginosa
Eur. J. Biochem.
31
290-295
1972
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