Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.1 extracted from

  • Hinde, R.W.; Jacobson, J.A.; Weiss, R.L.; Davis, R.H.
    N-Acetyl-L-glutamate synthase of Neurospora crassa. Characteristics, localization, regulation, and genetic control (1986), J. Biol. Chem., 261, 5848-5852.
    View publication on PubMed
Search for more literature for 2.3.1.1

Inhibitors

Inhibitors Comment Organism Structure
arginine feed back inhibition, 0.16 mM, 50% inhibition; L-arginine Neurospora crassa
coenzyme A 1 mM, 30% inhibition Neurospora crassa
oxaloacetate 1 mM, 68% inhibition Neurospora crassa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.6
-
 glutamate
-
 Neurospora crassa
6.3
-
 acetyl-CoA
-
 Neurospora crassa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + L-glutamate Neurospora crassa indispensible enzyme of arginine biosynthesis CoA + N-acetyl-L-glutamate
-
 ?

Organism

Organism UniProt Comment Textmining
Neurospora crassa
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + L-glutamate
-
 Neurospora crassa CoA + N-acetyl-L-glutamate
-
 ?
acetyl-CoA + L-glutamate indispensible enzyme of arginine biosynthesis Neurospora crassa CoA + N-acetyl-L-glutamate
-
 ?
propionyl-CoA + L-glutamate 18% of activity with acetyl-CoA Neurospora crassa CoA + N-propionyl-L-glutamate
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.8 9
-
 Neurospora crassa

pH Range

pH Minimum pH Maximum Comment Organism
8 9.5 38% of maximal activity at pH 8.0., 25% of maximal activity at pH 9.5 Neurospora crassa