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Literature summary for 2.2.1.8 extracted from

  • Murphy, C.D.; Schaffrath, C.; O'Hagan, D.
    Fluorinated natural products: the biosynthesis of fluoroacetate and 4-fluorothreonine in Streptomyces cattleya (2003), Chemosphere, 52, 455-461.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-threonine + fluoroacetaldehyde Streptomyces cattleya enzyme is important in biosynthesis of 4-fluorothreonine acetaldehyde + 4-fluoro-L-threonine
-
?
L-threonine + fluoroacetaldehyde Streptomyces cattleya NRRL 8057 enzyme is important in biosynthesis of 4-fluorothreonine acetaldehyde + 4-fluoro-L-threonine
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?

Organism

Organism UniProt Comment Textmining
Streptomyces cattleya
-
NRRL 8057
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Streptomyces cattleya NRRL 8057
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NRRL 8057
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-threonine + chloroacetaldehyde
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Streptomyces cattleya acetaldehyde + 4-chloro-L-threonine
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?
L-threonine + chloroacetaldehyde
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Streptomyces cattleya NRRL 8057 acetaldehyde + 4-chloro-L-threonine
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?
L-threonine + fluoroacetaldehyde C3 and C4 of threonine are replaced with the aldehyde carbons, generating a new molecule of threonine Streptomyces cattleya acetaldehyde + 4-fluoro-L-threonine
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?
L-threonine + fluoroacetaldehyde enzyme is important in biosynthesis of 4-fluorothreonine Streptomyces cattleya acetaldehyde + 4-fluoro-L-threonine
-
?
L-threonine + fluoroacetaldehyde C3 and C4 of threonine are replaced with the aldehyde carbons, generating a new molecule of threonine Streptomyces cattleya NRRL 8057 acetaldehyde + 4-fluoro-L-threonine
-
?
L-threonine + fluoroacetaldehyde enzyme is important in biosynthesis of 4-fluorothreonine Streptomyces cattleya NRRL 8057 acetaldehyde + 4-fluoro-L-threonine
-
?

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate pyridoxal 5'-phosphate protein Streptomyces cattleya