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Literature summary for 2.2.1.7 extracted from

  • Chen, P.Y.; DeColli, A.A.; Freel Meyers, C.L.; Drennan, C.L.
    X-ray crystallography-based structural elucidation of enzyme-bound intermediates along the 1-deoxy-D-xylulose 5-phosphate synthase reaction coordinate (2019), J. Biol. Chem., 294, 12405-12414 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.2.1.7

Crystallization (Commentary)

Crystallization (Comment) Organism
enzyme bound to C2alpha-phosphonolactyl-thiamine diphosphate and a native post-decarboxylation state with a bound enamine intermediate Deinococcus radiodurans

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.011
-
 pyruvate pH and temperature not specified in the publication Deinococcus radiodurans
0.054
-
 D-glyceraldehyde 3-phosphate pH and temperature not specified in the publication Deinococcus radiodurans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pyruvate + D-glyceraldehyde 3-phosphate Deinococcus radiodurans
-
 1-deoxy-D-xylulose 5-phosphate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Deinococcus radiodurans
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyruvate + D-glyceraldehyde 3-phosphate
-
 Deinococcus radiodurans 1-deoxy-D-xylulose 5-phosphate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
1-deoxy-D-xylulose 5-phosphate synthase
-
 Deinococcus radiodurans
DXPS
-
 Deinococcus radiodurans

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.75
-
 D-glyceraldehyde 3-phosphate pH and temperature not specified in the publication Deinococcus radiodurans

Cofactor

Cofactor Comment Organism Structure
thiamine diphosphate
-
 Deinococcus radiodurans