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Literature summary for 2.2.1.7 extracted from
- Challenges and hallmarks of establishing alkylacetylphosphonates as probes of bacterial 1-deoxy-D-xylulose 5-phosphate synthase (2017), ACS Infect. Dis., 3, 467-478 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli BL21(DE3) cells | Escherichia coli |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| benzylacetylphosphonate | - |
Escherichia coli |  |
| butylacetylphosphonate | - |
Escherichia coli | |
| ethyl acetylphosphonate | - |
Escherichia coli | |
| hexyl acetylphosphonate | - |
Escherichia coli | |
| isopropylacetylphosphonate | weak inhibition | Escherichia coli | |
| methyl acetylphosphonate | - |
Escherichia coli | |
| octyl acetylphosphonate | - |
Escherichia coli | |
| pentyl acetylphosphonate | - |
Escherichia coli | |
| propyl acetylphosphonate | - |
Escherichia coli | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pyruvate + D-glyceraldehyde 3-phosphate | Escherichia coli | - |
1-deoxy-D-xylulose 5-phosphate + CO2 | - |
? | |
| pyruvate + D-glyceraldehyde 3-phosphate | Escherichia coli MG1655 | - |
1-deoxy-D-xylulose 5-phosphate + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
| Escherichia coli MG1655 | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pyruvate + D-glyceraldehyde 3-phosphate | - |
Escherichia coli | 1-deoxy-D-xylulose 5-phosphate + CO2 | - |
? | |
| pyruvate + D-glyceraldehyde 3-phosphate | - |
Escherichia coli MG1655 | 1-deoxy-D-xylulose 5-phosphate + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DXP synthase | - |
Escherichia coli |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| thiamine diphosphate | - |
Escherichia coli | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.001 | - |
methyl acetylphosphonate | at pH 8.0 and 37°C | Escherichia coli | |
| 0.0014 | - |
octyl acetylphosphonate | at pH 8.0 and 37°C | Escherichia coli | |
| 0.0017 | - |
pentyl acetylphosphonate | at pH 8.0 and 37°C | Escherichia coli | |
| 0.0056 | - |
butylacetylphosphonate | at pH 8.0 and 37°C | Escherichia coli | |
| 0.00671 | - |
ethyl acetylphosphonate | at pH 8.0 and 37°C | Escherichia coli | |
| 0.0071 | - |
propyl acetylphosphonate | at pH 8.0 and 37°C | Escherichia coli | |
| 0.0089 | - |
hexyl acetylphosphonate | at pH 8.0 and 37°C | Escherichia coli | |
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