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Literature summary for 2.2.1.6 extracted from

  • Li, K.J.; Qu, R.Y.; Liu, Y.C.; Yang, J.F.; Devendar, P.; Chen, Q.; Niu, C.W.; Xi, Z.; Yang, G.F.
    Design, synthesis, and herbicidal activity of pyrimidine-biphenyl hybrids as novel acetohydroxyacid synthase inhibitors (2018), J. Agric. Food Chem., 66, 3773-3782 .
    View publication on PubMed
Search for more literature for 2.2.1.6

Inhibitors

Inhibitors Comment Organism Structure
1-methoxy-1-oxopropan-2-yl 3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methyl[1,1'-biphenyl]-2-carboxylate
-
 Arabidopsis thaliana
2'-chloro-3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methylbiphenyl-2-carboxylic acid
-
 Arabidopsis thaliana
2-(5-chloropyridin-3-yl)-6-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4-methylbenzoic acid
-
 Arabidopsis thaliana
2-(6-chloropyridin-3-yl)-6-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4-methylbenzoic acid
-
 Arabidopsis thaliana
2-ethoxy-2-oxoethyl 3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methyl[1,1'-biphenyl]-2-carboxylate
-
 Arabidopsis thaliana
2-methoxy-2-oxoethyl 3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methyl[1,1'-biphenyl]-2-carboxylate
-
 Arabidopsis thaliana
2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4-methyl-6-(5-methylpyridin-3-yl)benzoic acid
-
 Arabidopsis thaliana
2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4-methyl-6-(naphthalen-2-yl)benzoic acid
-
 Arabidopsis thaliana
2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4-methyl-6-(pyridin-3-yl)benzoic acid
-
 Arabidopsis thaliana
2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4-methyl-6-(pyrimidin-5-yl)benzoic acid
-
 Arabidopsis thaliana
2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-(2-methoxypyrimidin-5-yl)-4-methylbenzoic acid
-
 Arabidopsis thaliana
2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methylbenzoic acid
-
 Arabidopsis thaliana
2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-(6-fluoropyridin-3-yl)-4-methylbenzoic acid
-
 Arabidopsis thaliana
2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-(furan-2-yl)-4-methylbenzoic acid
-
 Arabidopsis thaliana
2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-(furan-3-yl)-4-methylbenzoic acid
-
 Arabidopsis thaliana
3'-chloro-3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methylbiphenyl-2-carboxylic acid
-
 Arabidopsis thaliana
3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-2'-fluoro-5-methylbiphenyl-2-carboxylic acid
-
 Arabidopsis thaliana
3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-3',5'-difluoro-5-methylbiphenyl-2-carboxylic acid
-
 Arabidopsis thaliana
3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-3'-fluoro-5-methylbiphenyl-2-carboxylic acid
-
 Arabidopsis thaliana
3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4',5-dimethylbiphenyl-2-carboxylic acid
-
 Arabidopsis thaliana
3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4'-fluoro-5-methylbiphenyl-2-carboxylic acid
-
 Arabidopsis thaliana
3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4'-methoxy-5-methylbiphenyl-2-carboxylic acid
-
 Arabidopsis thaliana
3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-fluorobiphenyl-2-carboxylic acid
-
 Arabidopsis thaliana
3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methoxybiphenyl-2-carboxylic acid
-
 Arabidopsis thaliana
3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methyl-4'-nitrobiphenyl-2-carboxylic acid
-
 Arabidopsis thaliana
3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methylbiphenyl-2-carboxylic acid
-
 Arabidopsis thaliana
3-[(4,6-dimethoxypyrimidin-2-yl)oxy]biphenyl-2-carboxylic acid
-
 Arabidopsis thaliana
4'-bromo-3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methylbiphenyl-2-carboxylic acid
-
 Arabidopsis thaliana
4'-chloro-3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methoxybiphenyl-2-carboxylic acid
-
 Arabidopsis thaliana
4'-chloro-3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methylbiphenyl-2-carboxylic acid
-
 Arabidopsis thaliana
5-chloro-3-[(4,6-dimethoxypyrimidin-2-yl)oxy]biphenyl-2-carboxylic acid
-
 Arabidopsis thaliana
bispyribac
-
 Arabidopsis thaliana
ethyl 3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methyl[1,1'-biphenyl]-2-carboxylate
-
 Arabidopsis thaliana
flumetsulam
-
 Arabidopsis thaliana
methyl 3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methylbiphenyl-2-carboxylate
-
 Arabidopsis thaliana
methyl 3-[(4,6-dimethoxypyrimidin-2-yl)oxy]biphenyl-2-carboxylate
-
 Arabidopsis thaliana
sodium 3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methylbiphenyl-2-carboxylate
-
 Arabidopsis thaliana
sodium 3-[(4,6-dimethoxypyrimidin-2-yl)oxy]biphenyl-2-carboxylate
-
 Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 pyruvate Arabidopsis thaliana
-
 2-acetolactate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana P17597
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 pyruvate
-
 Arabidopsis thaliana 2-acetolactate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
acetohydroxyacid synthase
-
 Arabidopsis thaliana
AHAS
-
 Arabidopsis thaliana

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00002
-
 3-[(4,6-dimethoxypyrimidin-2-yl)oxy]biphenyl-2-carboxylic acid pH and temperature not specified in the publication Arabidopsis thaliana
0.00009
-
 3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methylbiphenyl-2-carboxylic acid pH and temperature not specified in the publication Arabidopsis thaliana
0.00018
-
 3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4',5-dimethylbiphenyl-2-carboxylic acid pH and temperature not specified in the publication Arabidopsis thaliana
0.0002
-
 4'-chloro-3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methylbiphenyl-2-carboxylic acid pH and temperature not specified in the publication Arabidopsis thaliana
0.00025
-
 2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4-methyl-6-(naphthalen-2-yl)benzoic acid pH and temperature not specified in the publication Arabidopsis thaliana
0.00038
-
 flumetsulam pH and temperature not specified in the publication Arabidopsis thaliana
0.00041
-
 4'-bromo-3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methylbiphenyl-2-carboxylic acid pH and temperature not specified in the publication Arabidopsis thaliana
0.00051
-
 2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-(furan-3-yl)-4-methylbenzoic acid pH and temperature not specified in the publication Arabidopsis thaliana
0.00054
-
 bispyribac pH and temperature not specified in the publication Arabidopsis thaliana
0.00066
-
 2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-(furan-2-yl)-4-methylbenzoic acid pH and temperature not specified in the publication Arabidopsis thaliana
0.00067
-
 3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4'-fluoro-5-methylbiphenyl-2-carboxylic acid pH and temperature not specified in the publication Arabidopsis thaliana
0.00154
-
 3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4'-methoxy-5-methylbiphenyl-2-carboxylic acid pH and temperature not specified in the publication Arabidopsis thaliana
0.00207
-
 3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-2'-fluoro-5-methylbiphenyl-2-carboxylic acid pH and temperature not specified in the publication Arabidopsis thaliana
0.00215
-
 3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-3'-fluoro-5-methylbiphenyl-2-carboxylic acid pH and temperature not specified in the publication Arabidopsis thaliana
0.00273
-
 3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methyl-4'-nitrobiphenyl-2-carboxylic acid pH and temperature not specified in the publication Arabidopsis thaliana
0.00291
-
 2'-chloro-3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methylbiphenyl-2-carboxylic acid pH and temperature not specified in the publication Arabidopsis thaliana
0.00378
-
 2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methylbenzoic acid pH and temperature not specified in the publication Arabidopsis thaliana
0.00403
-
 3'-chloro-3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methylbiphenyl-2-carboxylic acid pH and temperature not specified in the publication Arabidopsis thaliana
0.00452
-
 2-(5-chloropyridin-3-yl)-6-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4-methylbenzoic acid pH and temperature not specified in the publication Arabidopsis thaliana
0.00531
-
 2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4-methyl-6-(pyridin-3-yl)benzoic acid pH and temperature not specified in the publication Arabidopsis thaliana
0.00728
-
 3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-3',5'-difluoro-5-methylbiphenyl-2-carboxylic acid pH and temperature not specified in the publication Arabidopsis thaliana
0.00989
-
 2-(6-chloropyridin-3-yl)-6-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4-methylbenzoic acid pH and temperature not specified in the publication Arabidopsis thaliana
0.0268
-
 3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methoxybiphenyl-2-carboxylic acid pH and temperature not specified in the publication Arabidopsis thaliana
0.0309
-
 2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-(6-fluoropyridin-3-yl)-4-methylbenzoic acid pH and temperature not specified in the publication Arabidopsis thaliana
0.0391
-
 4'-chloro-3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-methoxybiphenyl-2-carboxylic acid pH and temperature not specified in the publication Arabidopsis thaliana
0.0498
-
 2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4-methyl-6-(5-methylpyridin-3-yl)benzoic acid pH and temperature not specified in the publication Arabidopsis thaliana
0.0597
-
 2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-6-(2-methoxypyrimidin-5-yl)-4-methylbenzoic acid pH and temperature not specified in the publication Arabidopsis thaliana
0.663
-
 3-[(4,6-dimethoxypyrimidin-2-yl)oxy]-5-fluorobiphenyl-2-carboxylic acid pH and temperature not specified in the publication Arabidopsis thaliana
0.705
-
 2-[(4,6-dimethoxypyrimidin-2-yl)oxy]-4-methyl-6-(pyrimidin-5-yl)benzoic acid pH and temperature not specified in the publication Arabidopsis thaliana
1
-
 5-chloro-3-[(4,6-dimethoxypyrimidin-2-yl)oxy]biphenyl-2-carboxylic acid IC50 above 1.0 mM, pH and temperature not specified in the publication Arabidopsis thaliana