Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(3-fluorophenyl)-4-oxoquinazolin-3(4H)-yl 3-(trifluoromethyl)benzoate | 30% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
2-(3-fluorophenyl)-4-oxoquinazolin-3(4H)-yl 3-chlorobenzoate | 42.5% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
2-(3-fluorophenyl)-4-oxoquinazolin-3(4H)-yl 3-fluorobenzoate | 72% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
2-(3-fluorophenyl)-4-oxoquinazolin-3(4H)-yl 3-methoxybenzoate | 28% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
2-(3-fluorophenyl)-4-oxoquinazolin-3(4H)-yl benzoate | 26% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
2-(3-methoxyphenyl)-4-oxoquinazolin-3(4H)-yl 3-(trifluoromethyl)benzoate | 73.2% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
2-(3-methoxyphenyl)-4-oxoquinazolin-3(4H)-yl 3-chlorobenzoate | 23.5% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
2-(3-methoxyphenyl)-4-oxoquinazolin-3(4H)-yl 3-nitrobenzoate | 94% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
4-oxo-2-m-tolylquinazolin-3(4H)-yl 3-fluorobenzoate | 9.5% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
4-oxo-2-m-tolylquinazolin-3(4H)-yl 3-methylbenzoate | 10.5% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
4-oxo-2-m-tolylquinazolin-3(4H)-yl 4-chlorobenzoate | no inhibition at 0.1 mM | Mycobacterium tuberculosis | |
4-oxo-2-m-tolylquinazolin-3(4H)-yl 4-methylbenzoate | 33% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
4-oxo-2-m-tolylquinazolin-3(4H)-yl benzoate | 40.5% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
4-oxo-2-m-tolylquinazolin-3(4H)-yl-3-(trifluoromethyl)benzoate | 9.5% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
4-oxo-2-o-tolylquinazolin-3(4H)-yl 3-fluorobenzoate | 30% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
4-oxo-2-phenylquinazolin-3(4H)-yl 2-methylbenzoate | 16.5% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
4-oxo-2-phenylquinazolin-3(4H)-yl 3-chlorobenzoate | 80.5% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
4-oxo-2-phenylquinazolin-3(4H)-yl 3-fluorobenzoate | 26% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
4-oxo-2-phenylquinazolin-3(4H)-yl 3-methoxybenzoate | 27% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
4-oxo-2-phenylquinazolin-3(4H)-yl 3-methylbenzoate | 4% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
4-oxo-2-phenylquinazolin-3(4H)-yl 3-nitrobenzoate | 91.5% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
4-oxo-2-phenylquinazolin-3(4H)-yl 4-chlorobenzoate | 7.5% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
4-oxo-2-phenylquinazolin-3(4H)-yl 4-methylbenzoate | 18% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
4-oxo-2-phenylquinazolin-3(4H)-yl benzoate | 20.5% inhibition at 0.1 mM | Mycobacterium tuberculosis | |
isoniazid | - |
Mycobacterium tuberculosis | |
Rifampin | - |
Mycobacterium tuberculosis | |
sulfometuron methyl | - |
Mycobacterium tuberculosis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | 10 mM used in assay conditions | Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 pyruvate | Mycobacterium tuberculosis | - |
2-acetolactate + CO2 | - |
? | |
2 pyruvate | Mycobacterium tuberculosis H37Rv | - |
2-acetolactate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Mycobacterium tuberculosis H37Rv | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 pyruvate | - |
Mycobacterium tuberculosis | 2-acetolactate + CO2 | - |
? | |
2 pyruvate | - |
Mycobacterium tuberculosis H37Rv | 2-acetolactate + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
acetohydroxyacid synthase | - |
Mycobacterium tuberculosis |
acetolactate synthase | - |
Mycobacterium tuberculosis |
AHAS | - |
Mycobacterium tuberculosis |
ALS | - |
Mycobacterium tuberculosis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00479 | - |
at pH 7.5 and 37°C | Mycobacterium tuberculosis | sulfometuron methyl | |
0.0065 | - |
at pH 7.5 and 37°C | Mycobacterium tuberculosis | 2-(3-fluorophenyl)-4-oxoquinazolin-3(4H)-yl 3-fluorobenzoate | |
0.00874 | - |
at pH 7.5 and 37°C | Mycobacterium tuberculosis | 2-(3-methoxyphenyl)-4-oxoquinazolin-3(4H)-yl 3-nitrobenzoate | |
0.00957 | - |
at pH 7.5 and 37°C | Mycobacterium tuberculosis | 2-(3-methoxyphenyl)-4-oxoquinazolin-3(4H)-yl 3-(trifluoromethyl)benzoate | |
0.00968 | - |
at pH 7.5 and 37°C | Mycobacterium tuberculosis | 4-oxo-2-phenylquinazolin-3(4H)-yl 3-nitrobenzoate | |
0.01208 | - |
at pH 7.5 and 37°C | Mycobacterium tuberculosis | 4-oxo-2-phenylquinazolin-3(4H)-yl 3-chlorobenzoate | |
0.1 | - |
IC50 above 0.1 mM, at pH 7.5 and 37°C | Mycobacterium tuberculosis | 2-(3-fluorophenyl)-4-oxoquinazolin-3(4H)-yl 3-(trifluoromethyl)benzoate | |
0.1 | - |
IC50 above 0.1 mM, at pH 7.5 and 37°C | Mycobacterium tuberculosis | 2-(3-fluorophenyl)-4-oxoquinazolin-3(4H)-yl 3-chlorobenzoate | |
0.1 | - |
IC50 above 0.1 mM, at pH 7.5 and 37°C | Mycobacterium tuberculosis | 2-(3-fluorophenyl)-4-oxoquinazolin-3(4H)-yl 3-methoxybenzoate | |
0.1 | - |
IC50 above 0.1 mM, at pH 7.5 and 37°C | Mycobacterium tuberculosis | 2-(3-fluorophenyl)-4-oxoquinazolin-3(4H)-yl benzoate | |
0.1 | - |
IC50 above 0.1 mM, at pH 7.5 and 37°C | Mycobacterium tuberculosis | 2-(3-methoxyphenyl)-4-oxoquinazolin-3(4H)-yl 3-chlorobenzoate | |
0.1 | - |
IC50 above 0.1 mM, at pH 7.5 and 37°C | Mycobacterium tuberculosis | 4-oxo-2-m-tolylquinazolin-3(4H)-yl 3-fluorobenzoate | |
0.1 | - |
IC50 above 0.1 mM, at pH 7.5 and 37°C | Mycobacterium tuberculosis | 4-oxo-2-m-tolylquinazolin-3(4H)-yl 3-methylbenzoate | |
0.1 | - |
IC50 above 0.1 mM, at pH 7.5 and 37°C | Mycobacterium tuberculosis | 4-oxo-2-m-tolylquinazolin-3(4H)-yl 4-chlorobenzoate | |
0.1 | - |
IC50 above 0.1 mM, at pH 7.5 and 37°C | Mycobacterium tuberculosis | 4-oxo-2-m-tolylquinazolin-3(4H)-yl 4-methylbenzoate | |
0.1 | - |
IC50 above 0.1 mM, at pH 7.5 and 37°C | Mycobacterium tuberculosis | 4-oxo-2-m-tolylquinazolin-3(4H)-yl benzoate | |
0.1 | - |
IC50 above 0.1 mM, at pH 7.5 and 37°C | Mycobacterium tuberculosis | 4-oxo-2-m-tolylquinazolin-3(4H)-yl-3-(trifluoromethyl)benzoate | |
0.1 | - |
IC50 above 0.1 mM, at pH 7.5 and 37°C | Mycobacterium tuberculosis | 4-oxo-2-o-tolylquinazolin-3(4H)-yl 3-fluorobenzoate | |
0.1 | - |
IC50 above 0.1 mM, at pH 7.5 and 37°C | Mycobacterium tuberculosis | 4-oxo-2-phenylquinazolin-3(4H)-yl 2-methylbenzoate | |
0.1 | - |
IC50 above 0.1 mM, at pH 7.5 and 37°C | Mycobacterium tuberculosis | 4-oxo-2-phenylquinazolin-3(4H)-yl 3-fluorobenzoate | |
0.1 | - |
IC50 above 0.1 mM, at pH 7.5 and 37°C | Mycobacterium tuberculosis | 4-oxo-2-phenylquinazolin-3(4H)-yl 3-methoxybenzoate | |
0.1 | - |
IC50 above 0.1 mM, at pH 7.5 and 37°C | Mycobacterium tuberculosis | 4-oxo-2-phenylquinazolin-3(4H)-yl 3-methylbenzoate | |
0.1 | - |
IC50 above 0.1 mM, at pH 7.5 and 37°C | Mycobacterium tuberculosis | 4-oxo-2-phenylquinazolin-3(4H)-yl 4-chlorobenzoate | |
0.1 | - |
IC50 above 0.1 mM, at pH 7.5 and 37°C | Mycobacterium tuberculosis | 4-oxo-2-phenylquinazolin-3(4H)-yl 4-methylbenzoate | |
0.1 | - |
IC50 above 0.1 mM, at pH 7.5 and 37°C | Mycobacterium tuberculosis | 4-oxo-2-phenylquinazolin-3(4H)-yl benzoate |