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Literature summary for 2.2.1.6 extracted from
- Characterization of the catalytic properties of recombinant acetohydroxyacid synthase from tobacco (2005), Bull. Korean Chem. Soc., 26, 260-264.
No PubMed abstract available
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | the enzyme is the target of several herbicides | Nicotiana tabacum |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli strain DH5alpha | Nicotiana tabacum |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | steady-state kinetics at different reaction conditions | Nicotiana tabacum |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required, spectral analysis and kinetics of Mg2+ binding, overview | Nicotiana tabacum |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pyruvate | Nicotiana tabacum | the enzyme catalyzes the first committed step in the biosynthesis of valine, leucine, and isoleucine | 2-acetolactate + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Nicotiana tabacum | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pyruvate | - |
Nicotiana tabacum | 2-acetolactate + CO2 | - |
? | |
| pyruvate | the enzyme catalyzes the first committed step in the biosynthesis of valine, leucine, and isoleucine | Nicotiana tabacum | 2-acetolactate + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| acetohydroxy acid synthase | - |
Nicotiana tabacum |
| AHAS | - |
Nicotiana tabacum |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
standard assay at | Nicotiana tabacum |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
standard assay at | Nicotiana tabacum |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Nicotiana tabacum | |
| additional information | spectral analysis and kinetics of cofactor binding, overview | Nicotiana tabacum | |
| thiamine diphosphate | - |
Nicotiana tabacum | |
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Release 2023.1 (January 2023)
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