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Literature summary for 2.2.1.6 extracted from
- Monitoring the acetohydroxy acid synthase reaction and related carboligations by circular dichroism spectroscopy (2005), Anal. Biochem., 342, 126-133.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| glyoxylate | isozyme AHAS II | Escherichia coli |  |
| valine | isozyme AHAS I, feedback inhibition | Escherichia coli | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetics | Escherichia coli |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required | Escherichia coli | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
isozymes I-III | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
isozyme substrate specificities | Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| pyruvate | stereospecific reaction | Escherichia coli | (S)-2-acetolactate + CO2 | - |
? | |
| pyruvate + 2-oxobutyrate | stereospecific reaction | Escherichia coli | (S)-acetohydroxybutyrate + CO2 | - |
? | |
| pyruvate + benzaldehyde | stereospecific reaction | Escherichia coli | (R)-phenylacetylcarbinol + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| acetohydroxy acid synthase | - |
Escherichia coli |
| AHAS | - |
Escherichia coli |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
assay at | Escherichia coli |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.6 | - |
assay at | Escherichia coli |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Escherichia coli | |
| thiamine diphosphate | - |
Escherichia coli | |
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Release 2023.1 (January 2023)
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