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Literature summary for 2.2.1.6 extracted from

  • Blatt, J.M.; Pledger, W.J.; Umbarger, H.E.
    Isoleucine and valine metabolism in Escherichia coli. XX. Multiple forms of acetohydroxy acid synthetase (1972), Biochem. Biophys. Res. Commun., 48, 444-450.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Ile isoenzyme AHS I is sensitive to feed-back inhibition, isoenzyme AHS II is insensitive Escherichia coli
Leu isoenzyme AHS I is sensitive to feed-back inhibition, isoenzyme AHS II is insensitive Escherichia coli
Val isoenzyme AHS I is sensitive to feed-back inhibition, isoenzyme AHS II is insensitive Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pyruvate Escherichia coli production of isoenzyme AHS I is under multivalent control by Val and Leu, production of isoenzyme AHS II is under multivalent control by Ile, Val and Leu ?
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
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2 enzyme form AHS I and AHS II
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyruvate
-
Escherichia coli 2-acetolactate + CO2
-
?
pyruvate production of isoenzyme AHS I is under multivalent control by Val and Leu, production of isoenzyme AHS II is under multivalent control by Ile, Val and Leu Escherichia coli ?
-
?